112795-99-0Relevant articles and documents
Dihydropyrimidine calcium channel blockers. 3. 3-carbamoyl-4-aryl-1,2,3,4-tetrahydro-6-methyl-5-pyrimidinecarboxylic acid esters as orally effective antihypertensive agents
Atwal,Swanson,Unger,Floyd,Moreland,Hedberg,O'Reilly
, p. 806 - 811 (1991)
In order to explain the potent antihypertensive activity of the modestly active (IC50 = 3.2 μM) dihydropyrimidine calcium channel blocker 5, we carried out drug metabolism studies in the rat and found 5 is metabolized to compounds 6-10. Two of