(S)-methyl 2-(4,6-dimethoxypyrimidin-2-yloxy)-3-methoxy-3,3-diphenylpropionate

Base Information

Chemical Name:(S)-methyl 2-(4,6-dimethoxypyrimidin-2-yloxy)-3-methoxy-3,3-diphenylpropionate
CAS No.:177036-79-2
Molecular Formula:C₂₃H₂₄N₂O₆
Molecular Weight:424.453
Hs Code.:

Synonyms:(S)-methyl 2-(4,6-dimethoxypyrimidin-2-yloxy)-3-methoxy-3,3-diphenylpropionate

Suppliers and Price of (S)-methyl 2-(4,6-dimethoxypyrimidin-2-yloxy)-3-methoxy-3,3-diphenylpropionate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-methyl 2-(4,6-dimethoxypyrimidin-2-yloxy)-3-methoxy-3,3-diphenylpropionate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (S)-methyl 2-(4,6-dimethoxypyrimidin-2-yloxy)-3-methoxy-3,3-diphenylpropionate

There total 6 articles about (S)-methyl 2-(4,6-dimethoxypyrimidin-2-yloxy)-3-methoxy-3,3-diphenylpropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.1%

: 113583-35-0
4,6-dimethoxypyrimidin-2-yl methyl sulfone

: 177036-78-1
(S)-2-hydroxy-3-methoxy-3,3-diphenylpropionic acid methyl ester

: 177036-79-2
(S)-methyl 2-(4,6-dimethoxypyrimidin-2-yloxy)-3-methoxy-3,3-diphenylpropionate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 90 - 92 ℃; for 1.5h; Inert atmosphere;

Reference yield:

: 178306-52-0,178306-49-5
(S)-2-hydroxy-3-methoxy-3,3-diphenylpropionic acid

: 177036-79-2
(S)-methyl 2-(4,6-dimethoxypyrimidin-2-yloxy)-3-methoxy-3,3-diphenylpropionate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium methylate / N,N-dimethyl-formamide / 5 - 28 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 1.5 h / 90 - 92 °C / Inert atmosphere

With sodium methylate; potassium carbonate; In N,N-dimethyl-formamide;

Reference yield:

: 178306-51-9,178306-49-5
(S)-2-hydroxy-3-methoxy-3,3-diphenyl propionic acid

: 177036-79-2
(S)-methyl 2-(4,6-dimethoxypyrimidin-2-yloxy)-3-methoxy-3,3-diphenylpropionate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium methylate; L-proline methyl ester monohydrochloride / tert-butyl methyl ether; methanol / 1.25 h / 25 - 60 °C / Reflux

2.1: toluene-4-sulfonic acid / 48 h / 25 - 35 °C

3.1: potassium carbonate / acetone / 0.67 h / 25 - 35 °C

3.2: 10 h / 55 - 60 °C

With sodium methylate; L-proline methyl ester monohydrochloride; potassium carbonate; toluene-4-sulfonic acid; In methanol; tert-butyl methyl ether; acetone;