2-(4-methoxy-2-trifluoromethylphenyl)-5-triisopropylsilanyloxymethyl-[1,3,4]thiadiazole

Base Information

Chemical Name:2-(4-methoxy-2-trifluoromethylphenyl)-5-triisopropylsilanyloxymethyl-[1,3,4]thiadiazole
CAS No.:1350351-92-6
Molecular Formula:C₂₀H₂₉F₃N₂O₂SSi
Molecular Weight:446.609
Hs Code.:

Synonyms:2-(4-methoxy-2-trifluoromethylphenyl)-5-triisopropylsilanyloxymethyl-[1,3,4]thiadiazole

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Chemical Property of 2-(4-methoxy-2-trifluoromethylphenyl)-5-triisopropylsilanyloxymethyl-[1,3,4]thiadiazole

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Technology Process of 2-(4-methoxy-2-trifluoromethylphenyl)-5-triisopropylsilanyloxymethyl-[1,3,4]thiadiazole

There total 1 articles about 2-(4-methoxy-2-trifluoromethylphenyl)-5-triisopropylsilanyloxymethyl-[1,3,4]thiadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1350351-90-4
2-bromo-5-triisopropylsilanyloxymethyl-[1,3,4]thiadiazole

: 313546-16-6
(4-methoxy-2-(trifluoromethyl)phenyl)boronic acid

: 1350351-92-6
2-(4-methoxy-2-trifluoromethylphenyl)-5-triisopropylsilanyloxymethyl-[1,3,4]thiadiazole

Guidance literature:: With phosphate potassium salt; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,2-dimethoxyethane; water; at 80 ℃; for 3h; Inert atmosphere;

Reference yield: 69.0%

: 1350351-92-6
2-(4-methoxy-2-trifluoromethylphenyl)-5-triisopropylsilanyloxymethyl-[1,3,4]thiadiazole

: 1350351-93-7
[5-(4-methoxy-2-trifluoromethylphenyl)-[1,3,4]thiadiazol-2-yl]-methanol

Guidance literature:: 2-(4-methoxy-2-trifluoromethylphenyl)-5-triisopropylsilanyloxymethyl-[1,3,4]thiadiazole; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 1h;

With water;

Reference yield:

: 1350351-92-6
2-(4-methoxy-2-trifluoromethylphenyl)-5-triisopropylsilanyloxymethyl-[1,3,4]thiadiazole

: 1350352-16-7
7-bromo-6-(2-fluorophenyl)-3-[5-(4-methoxy-2-trifluoromethylphenyl)-[1,3,4]thiadiazol-2-ylmethyl]-3H-pyrrolo[3,2-d]pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

2: pyridine / dichloromethane / 1 h / 20 °C

3: N,N-dimethyl-formamide / 18 h / 65 - 85 °C

With pyridine; tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;