(R)-(2-(hydroxymethyl)aziridin-1-yl)-(3-methoxy-4-nitrophenyl)methanone

Base Information

Chemical Name:(R)-(2-(hydroxymethyl)aziridin-1-yl)-(3-methoxy-4-nitrophenyl)methanone
CAS No.:1618664-08-6
Molecular Formula:C₁₁H₁₂N₂O₅
Molecular Weight:252.227
Hs Code.:

Synonyms:(R)-(2-(hydroxymethyl)aziridin-1-yl)-(3-methoxy-4-nitrophenyl)methanone

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Chemical Property of (R)-(2-(hydroxymethyl)aziridin-1-yl)-(3-methoxy-4-nitrophenyl)methanone

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Technology Process of (R)-(2-(hydroxymethyl)aziridin-1-yl)-(3-methoxy-4-nitrophenyl)methanone

There total 4 articles about (R)-(2-(hydroxymethyl)aziridin-1-yl)-(3-methoxy-4-nitrophenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1618663-82-3
methanesulfonic acid 1-(3-methoxy-4-nitrobenzoyl)aziridin-2-ylmethyl ester

: 1618664-08-6
(R)-(2-(hydroxymethyl)aziridin-1-yl)-(3-methoxy-4-nitrophenyl)methanone

: 1618664-09-7
(S)-(2-(hydroxymethyl)aziridin-1-yl)-(3-methoxy-4-nitrophenyl)methanone

Guidance literature:: methanesulfonic acid 1-(3-methoxy-4-nitrobenzoyl)aziridin-2-ylmethyl ester; With potassium acetate; In dimethyl sulfoxide; at 100 ℃; for 16h;

With methanol; sodium hydroxide; at 20 ℃;

Reference yield:

: 1672672-54-6
methanesulfonic acid 3-methanesulfonyloxy-2-(3-methoxy-4-nitrobenzoylamino)propyl

: 1618664-08-6
(R)-(2-(hydroxymethyl)aziridin-1-yl)-(3-methoxy-4-nitrophenyl)methanone

: 1618664-09-7
(S)-(2-(hydroxymethyl)aziridin-1-yl)-(3-methoxy-4-nitrophenyl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / 2 h / 50 °C

2.1: potassium acetate / dimethyl sulfoxide / 16 h / 100 °C

2.2: 20 °C

With potassium acetate; sodium hydride; In dimethyl sulfoxide;

Reference yield:

: 67579-92-4
3-methoxy-4-nitrobenzoic acid chloride

: 1618664-08-6
(R)-(2-(hydroxymethyl)aziridin-1-yl)-(3-methoxy-4-nitrophenyl)methanone

: 1618664-09-7
(S)-(2-(hydroxymethyl)aziridin-1-yl)-(3-methoxy-4-nitrophenyl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 0.25 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.5 h / 0 - 20 °C

3.1: sodium hydride / 2 h / 50 °C

4.1: potassium acetate / dimethyl sulfoxide / 16 h / 100 °C

4.2: 20 °C

With potassium acetate; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; dimethyl sulfoxide;