methyl (R)-7-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-2H-inden-1-yl)-2-oxooctanoate

Base Information

Chemical Name:methyl (R)-7-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-2H-inden-1-yl)-2-oxooctanoate
CAS No.:1188932-04-8
Molecular Formula:C₃₉H₇₀O₅Si₂
Molecular Weight:675.153
Hs Code.:

methyl (R)-7-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-2H-inden-1-yl)-2-oxooctanoate

Synonyms:methyl (R)-7-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-2H-inden-1-yl)-2-oxooctanoate

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Chemical Property of methyl (R)-7-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-2H-inden-1-yl)-2-oxooctanoate

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Technology Process of methyl (R)-7-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-2H-inden-1-yl)-2-oxooctanoate

There total 7 articles about methyl (R)-7-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-2H-inden-1-yl)-2-oxooctanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1188932-03-7
(R,Z)-methyl-7-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)-2-(tert-butyldimethylsilyloxy)oct-2-enoate

: 1188932-04-8
methyl (R)-7-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-2H-inden-1-yl)-2-oxooctanoate

Guidance literature:: With acetic acid; cesium fluoride; In dichloromethane; acetonitrile; at 0 - 20 ℃;

Reference yield:

: (R,Z)-methyl-7-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis-(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)-2-(tert-butyldimethylsilyloxy)oct-2-enoate

: 1188932-04-8
methyl (R)-7-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-2H-inden-1-yl)-2-oxooctanoate

Guidance literature:: With acetic acid; cesium fluoride; In dichloromethane; acetonitrile; at 0 - 20 ℃;
DOI:10.1016/j.bmc.2010.03.078

Reference yield:

: 1188931-89-6
(R)-ethyl-5-((1R,3aR,7aR)-7a-methyl-4-oxo-octahydro-1H-inden-1-yl)hexanoate

: 1188932-04-8
methyl (R)-7-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-2H-inden-1-yl)-2-oxooctanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.08 h / -78 °C / Inert atmosphere; Cooling with ice

1.2: 3.08 h / -78 - 20 °C / Inert atmosphere

1.3: Saturated solution

2.1: diisobutylaluminium hydride / dichloromethane; toluene / -78 - 20 °C / Inert atmosphere

3.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

3.2: -78 - 20 °C

4.1: acetic acid; cesium fluoride / dichloromethane; acetonitrile / 0 - 20 °C

With sodium hexamethyldisilazane; diisobutylaluminium hydride; acetic acid; cesium fluoride; In tetrahydrofuran; dichloromethane; toluene; acetonitrile;