(R,Z)-methyl-7-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)-2-(tert-butyldimethylsilyloxy)oct-2-enoate

Base Information

Chemical Name:(R,Z)-methyl-7-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)-2-(tert-butyldimethylsilyloxy)oct-2-enoate
CAS No.:1188932-03-7
Molecular Formula:C₄₅H₈₄O₅Si₃
Molecular Weight:789.415
Hs Code.:

(R,Z)-methyl-7-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)-2-(tert-butyldimethylsilyloxy)oct-2-enoate

Synonyms:(R,Z)-methyl-7-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)-2-(tert-butyldimethylsilyloxy)oct-2-enoate

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Chemical Property of (R,Z)-methyl-7-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)-2-(tert-butyldimethylsilyloxy)oct-2-enoate

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Technology Process of (R,Z)-methyl-7-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)-2-(tert-butyldimethylsilyloxy)oct-2-enoate

There total 5 articles about (R,Z)-methyl-7-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)-2-(tert-butyldimethylsilyloxy)oct-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 957214-13-0
(5S)-5-((1R,3R,7E,17β)-1,3-bis[tert-butyl(dimethyl)silyloxy]-9,10-secoestra-5,7-dien-17-yl)hexanal

: 78186-95-5
methyl 2-(tert-butyldimethylsiloxy)-2-(dimethoxyphosphoryl)acetate

: 1188932-03-7
(R,Z)-methyl-7-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)-2-(tert-butyldimethylsilyloxy)oct-2-enoate

Guidance literature:: methyl 2-(tert-butyldimethylsiloxy)-2-(dimethoxyphosphoryl)acetate; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.25h; Inert atmosphere;

(5S)-5-((1R,3R,7E,17β)-1,3-bis[tert-butyl(dimethyl)silyloxy]-9,10-secoestra-5,7-dien-17-yl)hexanal; In tetrahydrofuran; at -78 - 20 ℃;

Reference yield:

: (S)-5-((1R,3aR,4S,7aR)-4-(tert-butyldimethylsilyloxy)-7a-methyloctahydro-1H-inden-1-yl)-1-ethoxyhex-1-ene

: 1188932-03-7
(R,Z)-methyl-7-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)-2-(tert-butyldimethylsilyloxy)oct-2-enoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridinium chlorochromate / dichloromethane / 3 h / Molecular sieve

1.2: 24 h / 20 °C

1.3: 3 h / 20 °C / Molecular sieve

2.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.08 h / -78 °C / Inert atmosphere; Cooling with ice

2.2: 3.08 h / -78 - 20 °C / Inert atmosphere

2.3: Saturated solution

3.1: diisobutylaluminium hydride / dichloromethane; toluene / -78 - 20 °C / Inert atmosphere

4.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

4.2: -78 - 20 °C

With sodium hexamethyldisilazane; diisobutylaluminium hydride; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; toluene;

Reference yield:

: 1188931-89-6
(R)-ethyl-5-((1R,3aR,7aR)-7a-methyl-4-oxo-octahydro-1H-inden-1-yl)hexanoate

: 1188932-03-7
(R,Z)-methyl-7-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)-2-(tert-butyldimethylsilyloxy)oct-2-enoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.08 h / -78 °C / Inert atmosphere; Cooling with ice

1.2: 3.08 h / -78 - 20 °C / Inert atmosphere

1.3: Saturated solution

2.1: diisobutylaluminium hydride / dichloromethane; toluene / -78 - 20 °C / Inert atmosphere

3.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

3.2: -78 - 20 °C

With sodium hexamethyldisilazane; diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane; toluene;