2-[(4-acetyl-phenylamino)-methylene]-malonic acid monoethyl ester

Base Information

• Chemical Name: 2-[(4-acetyl-phenylamino)-methylene]-malonic acid monoethyl ester
• CAS No.: 1415327-33-1
• Molecular Formula: C₁₄H₁₅NO₅
• Molecular Weight: 277.277
• Mol file: 1415327-33-1.mol

Synonyms:2-[(4-acetyl-phenylamino)-methylene]-malonic acid monoethyl ester

Chemical Property of 2-[(4-acetyl-phenylamino)-methylene]-malonic acid monoethyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 2-[(4-acetyl-phenylamino)-methylene]-malonic acid monoethyl ester

There total 2 articles about 2-[(4-acetyl-phenylamino)-methylene]-malonic acid monoethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-[(4-acetyl-phenylamino)-methylene]-malonic acid diethyl ester (104007-11-6) → 2-[(4-acetyl-phenylamino)-methylene]-malonic acid monoethyl ester (1415327-33-1)

Guidance literature:

With boron trifluoride diethyl etherate; In chloroform; at 20 ℃; for 2.3h; chemoselective reaction; Inert atmosphere;

DOI:10.1055/s-0031-1290449

Reference yield:

p-aminobenzophenone (99-92-3) + diethyl 2-ethoxymethylenemalonate (87-13-8) → 2-[(4-acetyl-phenylamino)-methylene]-malonic acid monoethyl ester (1415327-33-1)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 3 h / 20 °C

2: boron trifluoride diethyl etherate / chloroform / 2.3 h / 20 °C / Inert atmosphere

With boron trifluoride diethyl etherate; In ethanol; chloroform;

DOI:10.1055/s-0031-1290449

upstream raw materials:

p-aminobenzophenone

diethyl 2-ethoxymethylenemalonate

2-[(4-acetyl-phenylamino)-methylene]-malonic acid diethyl ester