5-(TERT-BUTYL)-2-HYDROXYISOPHTHALIC ACID

Base Information

• Chemical Name: 5-(TERT-BUTYL)-2-HYDROXYISOPHTHALIC ACID
• CAS No.: 157436-33-4
• Molecular Formula: C₁₂H₁₄O₅
• Molecular Weight: 238.24
• Mol file: 157436-33-4.mol

Synonyms:5-tert-butyl-2-hydroxybenzene-1,3-dioic acid

Chemical Property of 5-(TERT-BUTYL)-2-HYDROXYISOPHTHALIC ACID

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

5-(TERT-BUTYL)-2-HYDROXYISOPHTHALIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(TERT-BUTYL)-2-HYDROXYISOPHTHALIC ACID

There total 4 articles about 5-(TERT-BUTYL)-2-HYDROXYISOPHTHALIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

5-(tert-butyl)-2-methoxyisophthalic acid (97025-32-6) → 5-tert-butyl-2-hydroxybenzene-1,3-dioic acid (157436-33-4)

Guidance literature:

With hydrogen bromide; In acetic acid; at 120 ℃; for 0.166667h;

DOI:10.1002/hlca.19980810304

Reference yield:

para-tert-butylphenol (98-54-4) → 5-tert-butyl-2-hydroxybenzene-1,3-dioic acid (157436-33-4)

Guidance literature:

With tert-butylbenzene; n-heptane; n-pentylsodium; anschliessendes Umsetzen mit CO₂;

DOI:10.1021/ja01648a052

Reference yield:

4-tert-butyl-2,5-bis(hydroxymethyl)phenol (2203-14-7) → 5-tert-butyl-2-hydroxybenzene-1,3-dioic acid (157436-33-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / K₂CO₃ / acetone / 18 h / Heating

2: 97 percent / NaOH, Adogen 464, KMnO₄ / H₂O / 50 degC, 1 h, reflux, 5 min

3: 77 percent / HBr / acetic acid / 0.17 h / 120 °C

With sodium hydroxide; potassium permanganate; adogen 464; hydrogen bromide; potassium carbonate; In water; acetic acid; acetone;

DOI:10.1002/hlca.19980810304

upstream raw materials:

para-tert-butylphenol

5-(tert-butyl)-2-methoxyisophthalic acid

4-tert-butyl-2,5-bis(hydroxymethyl)phenol

1,3-Bis(hydroxymethyl)-5-tert-butyl-2-methoxybenzene

Downstream raw materials:

4-tert-butyl-2,6-bis[(4S,5S)-4,5-tetramethylene-1-(2,4,6-trimethylbenzenesulfonyl)imidazolin-2-yl]phenol