2-<2-(3,4-Dimethoxyphenyl)-2-hydroxyethyl>-1-<(4-methoxyphenyl)acetyl>piperidine

Base Information

• Chemical Name: 2-<2-(3,4-Dimethoxyphenyl)-2-hydroxyethyl>-1-<(4-methoxyphenyl)acetyl>piperidine
• CAS No.: 79228-19-6
• Molecular Formula: C₂₄H₃₁NO₅
• Molecular Weight: 413.514
• Mol file: 79228-19-6.mol

Synonyms:2-<2-(3,4-Dimethoxyphenyl)-2-hydroxyethyl>-1-<(4-methoxyphenyl)acetyl>piperidine

Chemical Property of 2-<2-(3,4-Dimethoxyphenyl)-2-hydroxyethyl>-1-<(4-methoxyphenyl)acetyl>piperidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-<2-(3,4-Dimethoxyphenyl)-2-hydroxyethyl>-1-<(4-methoxyphenyl)acetyl>piperidine

There total 11 articles about 2-<2-(3,4-Dimethoxyphenyl)-2-hydroxyethyl>-1-<(4-methoxyphenyl)acetyl>piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

2-<2(S*)-(3,4-Dimethoxyphenyl)-2-hydroxyethyl>piperidine (90243-11-1) + 4-methoxyphenyl-acetic chloride (4693-91-8) → (4-Methoxy-phenyl)-acetic acid (S)-1-(3,4-dimethoxy-phenyl)-2-{(R)-1-[2-(4-methoxy-phenyl)-acetyl]-piperidin-2-yl}-ethyl ester (90171-75-8) + 2-<2-(3,4-Dimethoxyphenyl)-2-hydroxyethyl>-1-<(4-methoxyphenyl)acetyl>piperidine (79228-19-6)

Guidance literature:

With potassium carbonate; In acetonitrile; for 1h; Yields of byproduct given; Ambient temperature;

DOI:10.1021/jo00187a022

Reference yield:

1-(3,4-dimethoxyphenyl)-2-(2-piperidyl)ethanol (20784-00-3,84416-05-7) + 4-methoxyphenyl-acetic chloride (4693-91-8) → 3-(3,4-Dimethoxy-phenyl)-1-(4-methoxy-phenyl)-4-{1-[2-(4-methoxy-phenyl)-acetyl]-piperidin-2-yl}-butan-2-one + 1-{2-[2-(3,4-Dimethoxy-phenyl)-2-hydroxy-ethyl]-piperidin-1-yl}-2-(4-methoxy-phenyl)-ethanone (79228-19-6)

Guidance literature:

With potassium carbonate; In dichloromethane; at 0 ℃; for 4h;

DOI:10.1016/S0040-4039(01)90476-9

Reference yield:

2,3,4,5-tetrahydropyridine N-oxide (34418-91-2) → 1-{2-[2-(3,4-Dimethoxy-phenyl)-2-hydroxy-ethyl]-piperidin-1-yl}-2-(4-methoxy-phenyl)-ethanone (79228-19-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 93 percent / toluene / Heating

2: 90 percent / Zn / aq. acetic acid / 2.5 h / Ambient temperature

3: K₂CO₃ / 4 h / 0 °C

4: K₂CO₃ / H₂O; methanol / 1 h / Heating

With potassium carbonate; zinc; In methanol; water; acetic acid; toluene;

DOI:10.1016/S0040-4039(01)90476-9

upstream raw materials:

1-(3,4-dimethoxyphenyl)-2-(2-piperidyl)ethanol

4-methoxyphenyl-acetic chloride

2-<2(S*)-(3,4-Dimethoxyphenyl)-2-hydroxyethyl>piperidine

2,3,4,5-tetrahydropyridine N-oxide

Downstream raw materials:

1-(3,4-Dimethoxyphenyl)-2-<1-<(4-methoxyphenyl)acetyl>piperidin-2-yl>ethanone

2-(3,4-dimethoxyphenyl)-3-(4-methoxyphenyl)-1,6,7,8,9,9a-hexahydro-4H-quinolizin-4-one

2-(3,4-Dimethoxyphenyl)-1,6,7,8,9,9a-hexahydro-3-(4-methoxyphenyl)-4H-quinolizin-4-one