4-{3-[(5-morpholin-4-yl-pyridine-3-carbonyl)amino]benzylamino}quinazoline-8-carboxylic acid amide

Base Information

Chemical Name:4-{3-[(5-morpholin-4-yl-pyridine-3-carbonyl)amino]benzylamino}quinazoline-8-carboxylic acid amide
CAS No.:1240475-57-3
Molecular Formula:C₂₆H₂₅N₇O₃
Molecular Weight:483.53
Hs Code.:

Synonyms:4-{3-[(5-morpholin-4-yl-pyridine-3-carbonyl)amino]benzylamino}quinazoline-8-carboxylic acid amide

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Chemical Property of 4-{3-[(5-morpholin-4-yl-pyridine-3-carbonyl)amino]benzylamino}quinazoline-8-carboxylic acid amide

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Technology Process of 4-{3-[(5-morpholin-4-yl-pyridine-3-carbonyl)amino]benzylamino}quinazoline-8-carboxylic acid amide

There total 9 articles about 4-{3-[(5-morpholin-4-yl-pyridine-3-carbonyl)amino]benzylamino}quinazoline-8-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1240480-59-4
4-{3-[(5-morpholin-4-yl-pyridine-3-carbonyl)amino]benzylamino}quinazoline-8-carboxylic acid methyl ester

: 1240475-57-3
4-{3-[(5-morpholin-4-yl-pyridine-3-carbonyl)amino]benzylamino}quinazoline-8-carboxylic acid amide

Guidance literature:: With ammonium hydroxide; In tetrahydrofuran; water; isopropyl alcohol; at 25 ℃; for 96h;

Reference yield:

: 29681-44-5
5-bromo-3-pyridine carboxylic acid methyl ester

: 1240475-57-3
4-{3-[(5-morpholin-4-yl-pyridine-3-carbonyl)amino]benzylamino}quinazoline-8-carboxylic acid amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 25 - 80 °C / Inert atmosphere

2.1: water; sodium hydroxide / methanol / 25 - 65 °C

2.2: pH 3

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 25 °C / Inert atmosphere

4.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 0 - 25 °C

5.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 25 - 50 °C / Inert atmosphere; capped vial

6.1: ammonium hydroxide / tetrahydrofuran; water; isopropyl alcohol / 96 h / 25 °C

With hydrogenchloride; ammonium hydroxide; water; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; toluene;

Reference yield:

: 263270-06-0
5-(morpholin-1-yl)nicotinic acid

: 1240475-57-3
4-{3-[(5-morpholin-4-yl-pyridine-3-carbonyl)amino]benzylamino}quinazoline-8-carboxylic acid amide

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 25 °C / Inert atmosphere

2: hydrogenchloride / 1,4-dioxane; dichloromethane / 0 - 25 °C

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 25 - 50 °C / Inert atmosphere; capped vial

4: ammonium hydroxide / tetrahydrofuran; water; isopropyl alcohol / 96 h / 25 °C

With hydrogenchloride; ammonium hydroxide; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;