N-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-4-methyl-3-(6-morpholin-4-ylmethyl-pyrimidin-4-yloxy)-benzamide

Base Information

Chemical Name:N-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-4-methyl-3-(6-morpholin-4-ylmethyl-pyrimidin-4-yloxy)-benzamide
CAS No.:1215029-09-6
Molecular Formula:C₂₉H₃₇N₅O₆S
Molecular Weight:583.709
Hs Code.:

Synonyms:N-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-4-methyl-3-(6-morpholin-4-ylmethyl-pyrimidin-4-yloxy)-benzamide

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Chemical Property of N-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-4-methyl-3-(6-morpholin-4-ylmethyl-pyrimidin-4-yloxy)-benzamide

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Technology Process of N-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-4-methyl-3-(6-morpholin-4-ylmethyl-pyrimidin-4-yloxy)-benzamide

There total 7 articles about N-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-4-methyl-3-(6-morpholin-4-ylmethyl-pyrimidin-4-yloxy)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

: 110-91-8,99108-56-2
morpholine

: 1215030-83-3
N-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-3-(6-formyl-pyrimidin-4-yloxy)-4-methyl-benzamide

: 1215029-09-6
N-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-4-methyl-3-(6-morpholin-4-ylmethyl-pyrimidin-4-yloxy)-benzamide

Guidance literature:: morpholine; N-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-3-(6-formyl-pyrimidin-4-yloxy)-4-methyl-benzamide; With acetic acid; In 1,2-dichloro-ethane; at 20 ℃; for 0.333333h;

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃;

With sodium hydrogencarbonate; In water; 1,2-dichloro-ethane;

Reference yield:

: 1215030-42-4
N-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-3-(2-chloro-pyrimidin-4-yloxy)-4-methyl-benzamide

: 1215029-09-6
N-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-4-methyl-3-(6-morpholin-4-ylmethyl-pyrimidin-4-yloxy)-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide; acetonitrile / 15 h / 70 °C / Inert atmosphere

2.1: diisobutylaluminium hydride / tetrahydrofuran / -65 - 20 °C / Inert atmosphere

3.1: acetic acid / 1,2-dichloro-ethane / 0.33 h / 20 °C

3.2: 20 °C

With diisobutylaluminium hydride; acetic acid; triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1215030-28-6
3-benzyloxy-N-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-4-methyl-benzamide

: 1215029-09-6
N-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-4-methyl-3-(6-morpholin-4-ylmethyl-pyrimidin-4-yloxy)-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 20 °C / 2585.81 Torr

2.1: potassium carbonate / N,N-dimethyl-formamide; acetonitrile / 20 °C

3.1: triethylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide; acetonitrile / 15 h / 70 °C / Inert atmosphere

4.1: diisobutylaluminium hydride / tetrahydrofuran / -65 - 20 °C / Inert atmosphere

5.1: acetic acid / 1,2-dichloro-ethane / 0.33 h / 20 °C

5.2: 20 °C

With hydrogen; diisobutylaluminium hydride; potassium carbonate; acetic acid; triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In tetrahydrofuran; methanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;