methyl 6-[5-(5-tert-butyl-3-methanesulphonyl-amino-2-methoxy-phenylaminocarbonyl)-2-methyl-phenoxy]-pyrimidine-4-carboxylate

Base Information

Chemical Name:methyl 6-[5-(5-tert-butyl-3-methanesulphonyl-amino-2-methoxy-phenylaminocarbonyl)-2-methyl-phenoxy]-pyrimidine-4-carboxylate
CAS No.:1215030-92-4
Molecular Formula:C₂₆H₃₀N₄O₇S
Molecular Weight:542.613
Hs Code.:

Synonyms:methyl 6-[5-(5-tert-butyl-3-methanesulphonyl-amino-2-methoxy-phenylaminocarbonyl)-2-methyl-phenoxy]-pyrimidine-4-carboxylate

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Chemical Property of methyl 6-[5-(5-tert-butyl-3-methanesulphonyl-amino-2-methoxy-phenylaminocarbonyl)-2-methyl-phenoxy]-pyrimidine-4-carboxylate

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Technology Process of methyl 6-[5-(5-tert-butyl-3-methanesulphonyl-amino-2-methoxy-phenylaminocarbonyl)-2-methyl-phenoxy]-pyrimidine-4-carboxylate

There total 5 articles about methyl 6-[5-(5-tert-butyl-3-methanesulphonyl-amino-2-methoxy-phenylaminocarbonyl)-2-methyl-phenoxy]-pyrimidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-56-1
methanol

: 201230-82-2
carbon monoxide

: 1215030-42-4
N-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-3-(2-chloro-pyrimidin-4-yloxy)-4-methyl-benzamide

: 1215030-92-4
methyl 6-[5-(5-tert-butyl-3-methanesulphonyl-amino-2-methoxy-phenylaminocarbonyl)-2-methyl-phenoxy]-pyrimidine-4-carboxylate

Guidance literature:: With triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In N,N-dimethyl-formamide; acetonitrile; at 70 ℃; for 15h; Inert atmosphere;

Reference yield:

: 1215030-28-6
3-benzyloxy-N-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-4-methyl-benzamide

: 1215030-92-4
methyl 6-[5-(5-tert-butyl-3-methanesulphonyl-amino-2-methoxy-phenylaminocarbonyl)-2-methyl-phenoxy]-pyrimidine-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 20 °C / 2585.81 Torr

2: potassium carbonate / N,N-dimethyl-formamide; acetonitrile / 20 °C

3: triethylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide; acetonitrile / 15 h / 70 °C / Inert atmosphere

With hydrogen; potassium carbonate; triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1215030-19-5
N-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-3-hydroxy-4-methyl-benzamide

: 1215030-92-4
methyl 6-[5-(5-tert-butyl-3-methanesulphonyl-amino-2-methoxy-phenylaminocarbonyl)-2-methyl-phenoxy]-pyrimidine-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide; acetonitrile / 20 °C

2: triethylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide; acetonitrile / 15 h / 70 °C / Inert atmosphere

With potassium carbonate; triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In N,N-dimethyl-formamide; acetonitrile;