(4S,6S)-4-{2-[(2S,4S)-4,6-Bis-(tert-butyl-dimethyl-silanyloxy)-2-(4-methoxy-benzyloxy)-hexyl]-[1,3]dithian-2-ylmethyl}-6-[2-(4-methoxy-benzyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxane

Base Information

Chemical Name:(4S,6S)-4-{2-[(2S,4S)-4,6-Bis-(tert-butyl-dimethyl-silanyloxy)-2-(4-methoxy-benzyloxy)-hexyl]-[1,3]dithian-2-ylmethyl}-6-[2-(4-methoxy-benzyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxane
CAS No.:815588-11-5
Molecular Formula:C₄₇H₈₀O₈S₂Si₂
Molecular Weight:893.45
Hs Code.:

(4S,6S)-4-{2-[(2S,4S)-4,6-Bis-(tert-butyl-dimethyl-silanyloxy)-2-(4-methoxy-benzyloxy)-hexyl]-[1,3]dithian-2-ylmethyl}-6-[2-(4-methoxy-benzyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxane

Synonyms:(4S,6S)-4-{2-[(2S,4S)-4,6-Bis-(tert-butyl-dimethyl-silanyloxy)-2-(4-methoxy-benzyloxy)-hexyl]-[1,3]dithian-2-ylmethyl}-6-[2-(4-methoxy-benzyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxane

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Chemical Property of (4S,6S)-4-{2-[(2S,4S)-4,6-Bis-(tert-butyl-dimethyl-silanyloxy)-2-(4-methoxy-benzyloxy)-hexyl]-[1,3]dithian-2-ylmethyl}-6-[2-(4-methoxy-benzyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxane

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Technology Process of (4S,6S)-4-{2-[(2S,4S)-4,6-Bis-(tert-butyl-dimethyl-silanyloxy)-2-(4-methoxy-benzyloxy)-hexyl]-[1,3]dithian-2-ylmethyl}-6-[2-(4-methoxy-benzyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxane

There total 14 articles about (4S,6S)-4-{2-[(2S,4S)-4,6-Bis-(tert-butyl-dimethyl-silanyloxy)-2-(4-methoxy-benzyloxy)-hexyl]-[1,3]dithian-2-ylmethyl}-6-[2-(4-methoxy-benzyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 627536-90-7
(4S,6S)-4-[1,3]Dithian-2-ylmethyl-6-[2-(4-methoxy-benzyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxane

: 815587-99-6
1-[(1S,3S)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-1-iodomethyl-pentyloxymethyl]-4-methoxy-benzene

: 815588-11-5
(4S,6S)-4-{2-[(2S,4S)-4,6-Bis-(tert-butyl-dimethyl-silanyloxy)-2-(4-methoxy-benzyloxy)-hexyl]-[1,3]dithian-2-ylmethyl}-6-[2-(4-methoxy-benzyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxane

Guidance literature:: (4S,6S)-4-[1,3]Dithian-2-ylmethyl-6-[2-(4-methoxy-benzyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxane; With tert.-butyl lithium; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; at -78 ℃; for 0.5h;

1-[(1S,3S)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-1-iodomethyl-pentyloxymethyl]-4-methoxy-benzene; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; at -78 ℃; for 0.5h;
DOI:10.1055/s-2004-831334

Reference yield:

: 89238-99-3
O-(4-methoxybenzyl)-trichloroacetimidate

: 815588-11-5
(4S,6S)-4-{2-[(2S,4S)-4,6-Bis-(tert-butyl-dimethyl-silanyloxy)-2-(4-methoxy-benzyloxy)-hexyl]-[1,3]dithian-2-ylmethyl}-6-[2-(4-methoxy-benzyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxane

Guidance literature:: Multi-step reaction with 8 steps

1.1: 94 percent / CSA / CH₂Cl₂ / 20 h / 20 °C

2.1: 88 percent / Zn / ethanol / 1 h / 70 °C

3.1: 84 percent / DIBALH / toluene / 1.5 h / -78 - 20 °C

4.1: 90 percent / DMAP; Et₃N / CH₂Cl₂ / 72 h / 20 °C

5.1: O₃ / CH₂Cl₂; methanol / -78 °C

5.2: 89 percent / NaBH₄ / CH₂Cl₂; methanol / 1.5 h / 20 °C

6.1: DMAP; Et₃N / CH₂Cl₂ / 1.5 h

7.1: NaI; NaHCO₃ / butan-2-one / 3 h / Heating

8.1: t-BuLi / hexamethylphosphoric acid triamide; tetrahydrofuran / 0.5 h / -78 °C

8.2: 88 percent / hexamethylphosphoric acid triamide; tetrahydrofuran / 0.5 h / -78 °C

With dmap; camphor-10-sulfonic acid; tert.-butyl lithium; diisobutylaluminium hydride; sodium hydrogencarbonate; ozone; triethylamine; sodium iodide; zinc; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; dichloromethane; toluene; butanone;
DOI:10.1055/s-2004-831334

Reference yield:

: 112065-93-7
ethyl 2-[(2R,4S,5S)-4-hydroxy-5-(iodomethyl)tetrahydro-2-furanyl]acetate

: 815588-11-5
(4S,6S)-4-{2-[(2S,4S)-4,6-Bis-(tert-butyl-dimethyl-silanyloxy)-2-(4-methoxy-benzyloxy)-hexyl]-[1,3]dithian-2-ylmethyl}-6-[2-(4-methoxy-benzyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxane

Guidance literature:: Multi-step reaction with 8 steps

1.1: 94 percent / CSA / CH₂Cl₂ / 20 h / 20 °C

2.1: 88 percent / Zn / ethanol / 1 h / 70 °C

3.1: 84 percent / DIBALH / toluene / 1.5 h / -78 - 20 °C

4.1: 90 percent / DMAP; Et₃N / CH₂Cl₂ / 72 h / 20 °C

5.1: O₃ / CH₂Cl₂; methanol / -78 °C

5.2: 89 percent / NaBH₄ / CH₂Cl₂; methanol / 1.5 h / 20 °C

6.1: DMAP; Et₃N / CH₂Cl₂ / 1.5 h

7.1: NaI; NaHCO₃ / butan-2-one / 3 h / Heating

8.1: t-BuLi / hexamethylphosphoric acid triamide; tetrahydrofuran / 0.5 h / -78 °C

8.2: 88 percent / hexamethylphosphoric acid triamide; tetrahydrofuran / 0.5 h / -78 °C

With dmap; camphor-10-sulfonic acid; tert.-butyl lithium; diisobutylaluminium hydride; sodium hydrogencarbonate; ozone; triethylamine; sodium iodide; zinc; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; dichloromethane; toluene; butanone;
DOI:10.1055/s-2004-831334