1-[(1S,3S)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-1-iodomethyl-pentyloxymethyl]-4-methoxy-benzene

Base Information

Chemical Name:1-[(1S,3S)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-1-iodomethyl-pentyloxymethyl]-4-methoxy-benzene
CAS No.:815587-99-6
Molecular Formula:C₂₆H₄₉IO₄Si₂
Molecular Weight:608.748
Hs Code.:

Synonyms:1-[(1S,3S)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-1-iodomethyl-pentyloxymethyl]-4-methoxy-benzene

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Chemical Property of 1-[(1S,3S)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-1-iodomethyl-pentyloxymethyl]-4-methoxy-benzene

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Technology Process of 1-[(1S,3S)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-1-iodomethyl-pentyloxymethyl]-4-methoxy-benzene

There total 7 articles about 1-[(1S,3S)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-1-iodomethyl-pentyloxymethyl]-4-methoxy-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Toluene-4-sulfonic acid (2S,4S)-4,6-bis-(tert-butyl-dimethyl-silanyloxy)-2-(4-methoxy-benzyloxy)-hexyl ester

: 815587-99-6
1-[(1S,3S)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-1-iodomethyl-pentyloxymethyl]-4-methoxy-benzene

Guidance literature:: With sodium hydrogencarbonate; sodium iodide; In butanone; for 3h; Heating;
DOI:10.1055/s-2004-831334

Reference yield:

: 89238-99-3
O-(4-methoxybenzyl)-trichloroacetimidate

: 815587-99-6
1-[(1S,3S)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-1-iodomethyl-pentyloxymethyl]-4-methoxy-benzene

Guidance literature:: Multi-step reaction with 7 steps

1.1: 94 percent / CSA / CH₂Cl₂ / 20 h / 20 °C

2.1: 88 percent / Zn / ethanol / 1 h / 70 °C

3.1: 84 percent / DIBALH / toluene / 1.5 h / -78 - 20 °C

4.1: 90 percent / DMAP; Et₃N / CH₂Cl₂ / 72 h / 20 °C

5.1: O₃ / CH₂Cl₂; methanol / -78 °C

5.2: 89 percent / NaBH₄ / CH₂Cl₂; methanol / 1.5 h / 20 °C

6.1: DMAP; Et₃N / CH₂Cl₂ / 1.5 h

7.1: NaI; NaHCO₃ / butan-2-one / 3 h / Heating

With dmap; camphor-10-sulfonic acid; diisobutylaluminium hydride; sodium hydrogencarbonate; ozone; triethylamine; sodium iodide; zinc; In methanol; ethanol; dichloromethane; toluene; butanone;
DOI:10.1055/s-2004-831334

Reference yield:

: (3S,5S)-5-(4-Methoxy-benzyloxy)-hept-6-ene-1,3-diol

: 815587-99-6
1-[(1S,3S)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-1-iodomethyl-pentyloxymethyl]-4-methoxy-benzene

Guidance literature:: Multi-step reaction with 4 steps

1.1: 90 percent / DMAP; Et₃N / CH₂Cl₂ / 72 h / 20 °C

2.1: O₃ / CH₂Cl₂; methanol / -78 °C

2.2: 89 percent / NaBH₄ / CH₂Cl₂; methanol / 1.5 h / 20 °C

3.1: DMAP; Et₃N / CH₂Cl₂ / 1.5 h

4.1: NaI; NaHCO₃ / butan-2-one / 3 h / Heating

With dmap; sodium hydrogencarbonate; ozone; triethylamine; sodium iodide; In methanol; dichloromethane; butanone;
DOI:10.1055/s-2004-831334