benzhydryl 7α-(2'-deuterioethynyl)-7β-<<(trifluoromethyl)sulfonyl>oxy>cephalosporanate

Base Information

Chemical Name:benzhydryl 7α-(2'-deuterioethynyl)-7β-<<(trifluoromethyl)sulfonyl>oxy>cephalosporanate
CAS No.:160032-81-5
Molecular Formula:C₂₆H₂₀F₃NO₈S₂
Molecular Weight:596.566
Hs Code.:

Synonyms:benzhydryl 7α-(2'-deuterioethynyl)-7β-<<(trifluoromethyl)sulfonyl>oxy>cephalosporanate

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Chemical Property of benzhydryl 7α-(2'-deuterioethynyl)-7β-<<(trifluoromethyl)sulfonyl>oxy>cephalosporanate

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Technology Process of benzhydryl 7α-(2'-deuterioethynyl)-7β-<<(trifluoromethyl)sulfonyl>oxy>cephalosporanate

There total 5 articles about benzhydryl 7α-(2'-deuterioethynyl)-7β-<<(trifluoromethyl)sulfonyl>oxy>cephalosporanate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 160032-80-4
benzhydryl 7α-(2'-deuterioethynyl)-7β-hydroxycephalosporanate

: 160032-81-5
benzhydryl 7α-(2'-deuterioethynyl)-7β-<<(trifluoromethyl)sulfonyl>oxy>cephalosporanate

Guidance literature:: With pyridine; In dichloromethane; at 0 - 20 ℃; for 0.5h;
DOI:10.1021/ja00103a010

Reference yield:

: 59128-53-9
benzhydryl 7-oxocephalosporanate

: 160032-81-5
benzhydryl 7α-(2'-deuterioethynyl)-7β-<<(trifluoromethyl)sulfonyl>oxy>cephalosporanate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 1.) -78 deg C, 1 h, 2.) -40 deg C, 1.5 h

2: 85 percent / pyridine / CH₂Cl₂ / 0.5 h / 0 - 20 °C

With pyridine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja00103a010

Reference yield:

: 27266-61-1,54600-89-4
benzhydryl 7-aminocephalosporanate

: 160032-81-5
benzhydryl 7α-(2'-deuterioethynyl)-7β-<<(trifluoromethyl)sulfonyl>oxy>cephalosporanate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) Et₃N, 2.) Tf₂O, 3.) HCl

2: tetrahydrofuran / 1.) -78 deg C, 1 h, 2.) -40 deg C, 1.5 h

3: 85 percent / pyridine / CH₂Cl₂ / 0.5 h / 0 - 20 °C

With pyridine; hydrogenchloride; trifluoromethylsulfonic anhydride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja00103a010