4,5-Dihydro-5-(hydroxy(3-(trifluoromethyl)phenyl)methyl)-6-methyl-3(2H)-pyridazinone

Base Information

Chemical Name:4,5-Dihydro-5-(hydroxy(3-(trifluoromethyl)phenyl)methyl)-6-methyl-3(2H)-pyridazinone
CAS No.:90060-90-5
Molecular Formula:C13H13F3N2O2
Molecular Weight:286.2497
Hs Code.:
DSSTox Substance ID:DTXSID701009129

Synonyms:3(2H)-Pyridazinone, 4,5-dihydro-5-(hydroxy(3-(trifluoromethyl)phenyl)methyl)-6-methyl-;4,5-Dihydro-5-(hydroxy(3-(trifluoromethyl)phenyl)methyl)-6-methyl-3(2H)-pyridazinone;Methyl-6 (trifluoromethyl-3' phenylhydroxymethyl)-5 dihydro-4,5(2H)pyridazinone-3 [French];90060-90-5;C13H13F3N2O2;Methyl-6 (trifluoromethyl-3' phenylhydroxymethyl)-5 dihydro-4,5(2H)pyridazinone-3;NIOSH/UR6371000;DTXSID701009129;C13-H13-F3-N2-O2;LS-129893;LS-129894;UR63710000;3(2H)-Pyridazinone, 4,5-dihydro-5-(alpha-hydroxy-m-(trifluoromethyl)benzyl)-6-methyl-;5-(alpha-Hydroxy-m-(trifluoromethyl)benzyl)-6-methyl-4,5-dihydro-3(2H)-pyridazinone;5-{Hydroxy[3-(trifluoromethyl)phenyl]methyl}-6-methyl-4,5-dihydropyridazin-3-ol;Methyl-6 (trifluoromethyl-3' phenyl-hydroxymethyl)-5 dihydro-4,5 (2H) pyridazinone-3;Methyl-6 (trifluoromethyl-3' phenyl-hydroxymethyl)-5 dihydro-4,5 (2H) pyridazinone-3 [French]

Suppliers and Price of 4,5-Dihydro-5-(hydroxy(3-(trifluoromethyl)phenyl)methyl)-6-methyl-3(2H)-pyridazinone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4,5-Dihydro-5-(hydroxy(3-(trifluoromethyl)phenyl)methyl)-6-methyl-3(2H)-pyridazinone

Chemical Property:

Refractive Index:1.557
Density:1.41g/cm³
XLogP3:1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:286.09291215
Heavy Atom Count:20
Complexity:409

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=NNC(=O)CC1C(C2=CC(=CC=C2)C(F)(F)F)O

Technology Process of 4,5-Dihydro-5-(hydroxy(3-(trifluoromethyl)phenyl)methyl)-6-methyl-3(2H)-pyridazinone

There total 1 articles about 4,5-Dihydro-5-(hydroxy(3-(trifluoromethyl)phenyl)methyl)-6-methyl-3(2H)-pyridazinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 88220-92-2,91478-23-8
(4R,5R)-4-Acetyl-5-(3-trifluoromethyl-phenyl)-dihydro-furan-2-one

: 90060-90-5,91478-03-4
(S)-5-[(R)-Hydroxy-(3-trifluoromethyl-phenyl)-methyl]-6-methyl-4,5-dihydro-2H-pyridazin-3-one

Guidance literature:: With hydrazine hydrate; In ethanol; for 2h; Heating;

Reference yield: 76.0%

: 90060-90-5
5-[Hydroxy-(3-trifluoromethyl-phenyl)-methyl]-6-methyl-4,5-dihydro-2H-pyridazin-3-one

: 90060-95-0
6-Methyl-5-[1-(3-trifluoromethyl-phenyl)-meth-(E)-ylidene]-4,5-dihydro-2H-pyridazin-3-one

Guidance literature:: With toluene-4-sulfonic acid; In toluene; for 3h; Heating;
DOI:10.1002/jhet.5570220630

Reference yield:

: 90060-90-5
5-[Hydroxy-(3-trifluoromethyl-phenyl)-methyl]-6-methyl-4,5-dihydro-2H-pyridazin-3-one

: 99300-77-3
Dimethyl-{6-methyl-5-[1-(3-trifluoromethyl-phenyl)-meth-(E)-ylidene]-4,5-dihydro-pyridazin-3-yl}-amine

Guidance literature:: Multi-step reaction with 2 steps

1: POCl₃ / 1.5 h / Heating

2: 95 percent / H₂O / 6 h / 160 °C

With trichlorophosphate; In water;
DOI:10.1002/jhet.5570220630