N-(5-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy)-2-methylphenyl)acetamide

Base Information

Chemical Name:N-(5-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy)-2-methylphenyl)acetamide
CAS No.:1354030-78-6
Molecular Formula:C₂₃H₂₉Cl₂N₃O₂
Molecular Weight:450.408
Hs Code.:

Synonyms:N-(5-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy)-2-methylphenyl)acetamide

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Chemical Property of N-(5-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy)-2-methylphenyl)acetamide

Chemical Property:

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Technology Process of N-(5-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy)-2-methylphenyl)acetamide

There total 6 articles about N-(5-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy)-2-methylphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1354030-77-5
5-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy)-2-methylaniline

: 75-36-5
acetyl chloride

: 1354030-78-6
N-(5-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy)-2-methylphenyl)acetamide

Guidance literature:: 5-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy)-2-methylaniline; acetyl chloride; With triethylamine; In dichloromethane; at 20 ℃;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

: 56961-77-4
1-bromo-2,3-dichlorobenzene

: 1354030-78-6
N-(5-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy)-2-methylphenyl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium t-butanolate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; 1,8-diazabicyclo[5.4.0]undec-7-ene / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 60 - 70 °C / Inert atmosphere

1.2: 20 °C

2.1: hydrogenchloride / ethyl acetate / 1.5 h / 20 °C

3.1: potassium carbonate / acetonitrile / Reflux

4.1: ammonium chloride; iron / ethanol; water / Reflux

5.1: triethylamine / dichloromethane / 20 °C

With hydrogenchloride; iron; potassium carbonate; ammonium chloride; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In ethanol; dichloromethane; water; ethyl acetate; toluene; acetonitrile;

Reference yield:

: 119532-26-2,864512-47-0
1-(2,3-dichlorophenyl)-piperazine hydrochloride

: 1354030-78-6
N-(5-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy)-2-methylphenyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / Reflux

2: ammonium chloride; iron / ethanol; water / Reflux

3: triethylamine / dichloromethane / 20 °C

With iron; potassium carbonate; ammonium chloride; triethylamine; In ethanol; dichloromethane; water; acetonitrile;