1-Tert-butyl2-Methyl4-hydroxypyrrolidine-1,2-dicarboxylate

Base Information

• Chemical Name: 1-Tert-butyl2-Methyl4-hydroxypyrrolidine-1,2-dicarboxylate
• CAS No.: 897046-42-3
• Molecular Formula: C₁₁H₁₉NO₅
• Molecular Weight: 245.276
• Mol file: 897046-42-3.mol

Synonyms:1-[(1,1-dimethylethoxy)-carbonyl]-4-hydroxy-2-pyrrolidine carboxylic acid methyl ester

Chemical Property of 1-Tert-butyl2-Methyl4-hydroxypyrrolidine-1,2-dicarboxylate

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

1-(tert-Butyl)2-methyl4-hydroxypyrrolidine-1,2-dicarboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 1-Tert-butyl2-Methyl4-hydroxypyrrolidine-1,2-dicarboxylate

There total 6 articles about 1-Tert-butyl2-Methyl4-hydroxypyrrolidine-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + acetone (67-64-1) + 3-hydroxy-dl-proline (51-35-4,30724-02-8) → 1-[(1,1-dimethylethoxy)-carbonyl]-4-hydroxy-2-pyrrolidine carboxylic acid methyl ester (897046-42-3)

Guidance literature:

With triethylamine; In water; at 0 ℃; for 16h;

Reference yield:

1-(tert-butyl) 2-methyl 4-(benzyloxy)pyrrolidine-1,2-dicarboxylate + argon → 1-[(1,1-dimethylethoxy)-carbonyl]-4-hydroxy-2-pyrrolidine carboxylic acid methyl ester (897046-42-3)

Guidance literature:

palladium-carbon; In ethyl acetate;

Reference yield:

N-tert-butoxycarbonyl-cis-4-formyloxy-L-proline methyl ester → 1-[(1,1-dimethylethoxy)-carbonyl]-4-hydroxy-2-pyrrolidine carboxylic acid methyl ester (897046-42-3)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran;

upstream raw materials:

di-tert-butyl dicarbonate

3-hydroxy-dl-proline

acetone

diazomethane

Downstream raw materials:

(2S,4R)-4-(methylsulfonyloxy)pyrrolidine-1,2-dicarboxylic acid 1-tert-butylester-2-methylester

tert-butyl 4-hydroxy-2-methylpyrrolidine-1-carboxylate

tert-butyl 2-methyl-4-oxopyrrolidine-1-carboxylate

N-((R)-1-(3-chlorophenyl)ethyl)-5-methyl-2-((tetrahydro-2H-pyran-4-yl)amino)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxamide

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