14β-phenylpropyl-17-cyclopropylmethyl-4,5α-epoxy-6-methylenemorphinan-3,14-triol

Base Information

Chemical Name:14β-phenylpropyl-17-cyclopropylmethyl-4,5α-epoxy-6-methylenemorphinan-3,14-triol
CAS No.:1032281-54-1
Molecular Formula:C₃₀H₃₅NO₃
Molecular Weight:457.613
Hs Code.:

Synonyms:14β-phenylpropyl-17-cyclopropylmethyl-4,5α-epoxy-6-methylenemorphinan-3,14-triol

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Chemical Property of 14β-phenylpropyl-17-cyclopropylmethyl-4,5α-epoxy-6-methylenemorphinan-3,14-triol

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Technology Process of 14β-phenylpropyl-17-cyclopropylmethyl-4,5α-epoxy-6-methylenemorphinan-3,14-triol

There total 5 articles about 14β-phenylpropyl-17-cyclopropylmethyl-4,5α-epoxy-6-methylenemorphinan-3,14-triol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1032281-51-8
17-cyclopropylmethyl-4,5α-epoxy-3-benzyloxy-14-(3'-phenylpropoxy)-6-methylene morphinan

: 1032281-54-1
14β-phenylpropyl-17-cyclopropylmethyl-4,5α-epoxy-6-methylenemorphinan-3,14-triol

Guidance literature:: With trifluoroacetic acid; for 1h; Heating / reflux;

Reference yield: 22.0%

: 14-(3'-phenylpropyl)nalmefene

: 1032281-54-1
14β-phenylpropyl-17-cyclopropylmethyl-4,5α-epoxy-6-methylenemorphinan-3,14-triol

Guidance literature:: 14-(3'-phenylpropyl)nalmefene; With boron tribromide; In dichloromethane; at -15 ℃; for 0.25h;

With ammonia; In dichloromethane; at 0 ℃; for 0.5h;

Reference yield:

: 144265-45-2
C₂₂H₂₇NO₃

: 1032281-54-1
14β-phenylpropyl-17-cyclopropylmethyl-4,5α-epoxy-6-methylenemorphinan-3,14-triol

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / Reflux

2.1: palladium on activated charcoal; hydrogen

3.1: boron tribromide / dichloromethane / 0.25 h / -15 °C

3.2: 0.5 h / 0 °C

With palladium on activated charcoal; hydrogen; boron tribromide; sodium hydride; In tetrahydrofuran; dichloromethane;