Chemical Property of Nalmefene
Chemical Property:
- Melting Point:182-185?C
- Boiling Point:507.9±50.0 °C(Predicted)
- PKA:pKa 7.63(H2O) (Uncertain)
- PSA：52.93000
- Density:1.38±0.1 g/cm3(Predicted)
- LogP:2.45040
- Storage Temp.:2-8°C
- Solubility.:Chloroform (Slightly), Dichloromethane (Slightly), DMSO (Slightly), Methanol (Sl
- XLogP3:2.7
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:2
- Exact Mass:339.18344366
- Heavy Atom Count:25
- Complexity:618
- Purity/Quality:
-
Nalmefene *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xi
- Hazard Codes:Xi
- Statements:
36/37/38
- Safety Statements:
26-36
- MSDS Files:
-
SDS file from LookChem
Total 1 MSDS from other Authors
Useful:
- Drug Classes:Opioid Antagonists
- Canonical SMILES:C=C1CCC2(C3CC4=C5C2(C1OC5=C(C=C4)O)CCN3CC6CC6)O
- Isomeric SMILES:C=C1CC[C@]2([C@H]3CC4=C5[C@]2([C@H]1OC5=C(C=C4)O)CCN3CC6CC6)O
- Recent ClinicalTrials:Title: Effect of Opioid Receptor Modulation on Alcohol Self-Administration and Neural Response to Alcohol Cues in Heavy Drinkers: Role of OPRM1 Gene Variation
- Recent EU Clinical Trials:Evaluation du nalméfène dans les troubles du contr?le des impulsions chez des patients ayant une maladie de Parkinson : une étude thérapeutique prospective ouverte
- Recent NIPH Clinical Trials:Efficacy and safety of Nalmefene in alcohol-dependent patients with chronic liver disease
-
Uses
A structural analog of Naltrexone (N285780) with opiate antagonist activity used in pharmaceutical treatment of alcoholism. Other pharmacological applications of Nalmefene aim to reduce food cravings, drug abuse and pulmonary disease in affected individuals. Used as an opioid-induced tranquilizer on large animals in the veterinary industry. Narcotic antagonist. A structural labelled analog of Naltrexone (N285780) with opiate antagonist activity used in pharmaceutical treatment of alcoholism. Other pharmacological applications of Nalmefene aim to reduce f
ood cravings, drug abuse and pulmonary disease in affected individuals. Used as an opioid-induced tranquilizer on large animals in the veterinary industry. Narcotic antagonist. opioid antagonists therapeutic for alcohol dependence
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Therapeutic Function
Antagonist to narcotics
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Biological Functions
Nalmefene (Revex) is a long-acting injectable pure opioid
antagonist recently introduced in the United States.
It binds all opioid receptors and reverses the effects of
opioid agonists at those receptors.The onset of action is 2 minutes after IV administration. Hepatic metabolism
is slow and occurs via glucuronide conjugation to inactive
metabolites. Its half-life of 11 hours is about 5 times
that of naloxone. Indications include use in postoperative
settings to reverse respiratory depression and in
opioid overdose. Due to the long duration of action of
nalmefene, however, naloxone may be preferred for
treatment of overdose because it produces a shorter duration
of withdrawal effects.
