(1R,2R,3R,7R,7aR)-1,2-bs(benzyloxy)-3-[(benzyloxy)methyl]hexahydro-1H-pyrrolizin-7-ol

Base Information

Chemical Name:(1R,2R,3R,7R,7aR)-1,2-bs(benzyloxy)-3-[(benzyloxy)methyl]hexahydro-1H-pyrrolizin-7-ol
CAS No.:137741-26-5
Molecular Formula:C₂₉H₃₃NO₄
Molecular Weight:459.585
Hs Code.:

Synonyms:(1R,2R,3R,7R,7aR)-1,2-bs(benzyloxy)-3-[(benzyloxy)methyl]hexahydro-1H-pyrrolizin-7-ol

Suppliers and Price of (1R,2R,3R,7R,7aR)-1,2-bs(benzyloxy)-3-[(benzyloxy)methyl]hexahydro-1H-pyrrolizin-7-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1R,2R,3R,7R,7aR)-1,2-bs(benzyloxy)-3-[(benzyloxy)methyl]hexahydro-1H-pyrrolizin-7-ol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1R,2R,3R,7R,7aR)-1,2-bs(benzyloxy)-3-[(benzyloxy)methyl]hexahydro-1H-pyrrolizin-7-ol

There total 17 articles about (1R,2R,3R,7R,7aR)-1,2-bs(benzyloxy)-3-[(benzyloxy)methyl]hexahydro-1H-pyrrolizin-7-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: (1R,2R,3R,6S,7S,7aS)-1,2,7-tris(benzyloxy)-3-[(benzyloxy)methyl]hexahydro-1H-pyrrolizin-6-yl methanesulfonate

: 137741-26-5
(1R,2R,3R,7R,7aR)-1,2-bs(benzyloxy)-3-[(benzyloxy)methyl]hexahydro-1H-pyrrolizin-7-ol

Guidance literature:: With diisobutylaluminium hydride; In toluene; at 0 ℃; for 2h; Inert atmosphere; Reflux;
DOI:10.1002/chem.201301320

Reference yield:

: (2R,3R,4R,5R)-2-((benzyloxy)methyl)-3,4-bis(benzyloxy)-5-(1-hydroxybut-3-en-1-yl)-N-(tert-butoxycarbonyl)pyrrolidine

: 137741-26-5
(1R,2R,3R,7R,7aR)-1,2-bs(benzyloxy)-3-[(benzyloxy)methyl]hexahydro-1H-pyrrolizin-7-ol

: 301310-42-9
(1R,2R,3R,7S,7aR)-1,2-dibenzyloxy-3-benzyloxymethyl-7-hydroxy-2,3,5,6,7,7a-hexahydro-1H-pyrrolizine

Guidance literature:: (2R,3R,4R,5R)-2-((benzyloxy)methyl)-3,4-bis(benzyloxy)-5-(1-hydroxybut-3-en-1-yl)-N-(tert-butoxycarbonyl)pyrrolidine; With ozone; In methanol; at -60 ℃;

With palladium 10% on activated carbon; hydrogen; acetic acid; In methanol; at 20 ℃; for 24h; under 760.051 Torr; Overall yield = 89 %;
DOI:10.1021/ol503728e

Reference yield:

: 302353-82-8
Toluene-4-sulfonic acid 2-[3-((1S,2R,3R)-3-azido-1,2,4-tris-benzyloxy-butyl)-oxiranyl]-ethyl ester

: 137741-26-5
(1R,2R,3R,7R,7aR)-1,2-bs(benzyloxy)-3-[(benzyloxy)methyl]hexahydro-1H-pyrrolizin-7-ol

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / 10percent Pd/C / diethyl ether; ethanol / 15 h / 23 °C / 760 Torr

2: K₂CO₃ / ethanol / 20 h / Heating

With hydrogen; potassium carbonate; palladium on activated charcoal; In diethyl ether; ethanol;
DOI:10.1016/0040-4039(91)80071-D