(1R,2R,3R,7S,7aR)-1,2-dibenzyloxy-3-benzyloxymethyl-7-hydroxy-2,3,5,6,7,7a-hexahydro-1H-pyrrolizine

Base Information

Chemical Name:(1R,2R,3R,7S,7aR)-1,2-dibenzyloxy-3-benzyloxymethyl-7-hydroxy-2,3,5,6,7,7a-hexahydro-1H-pyrrolizine
CAS No.:301310-42-9
Molecular Formula:C₂₉H₃₃NO₄
Molecular Weight:459.585
Hs Code.:

Synonyms:(1R,2R,3R,7S,7aR)-1,2-dibenzyloxy-3-benzyloxymethyl-7-hydroxy-2,3,5,6,7,7a-hexahydro-1H-pyrrolizine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,2R,3R,7S,7aR)-1,2-dibenzyloxy-3-benzyloxymethyl-7-hydroxy-2,3,5,6,7,7a-hexahydro-1H-pyrrolizine

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Technology Process of (1R,2R,3R,7S,7aR)-1,2-dibenzyloxy-3-benzyloxymethyl-7-hydroxy-2,3,5,6,7,7a-hexahydro-1H-pyrrolizine

There total 27 articles about (1R,2R,3R,7S,7aR)-1,2-dibenzyloxy-3-benzyloxymethyl-7-hydroxy-2,3,5,6,7,7a-hexahydro-1H-pyrrolizine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1357007-95-4
(1R,2R,3R,7S,7aS)-1,2-bis(benzyloxy)-3-benzyloxymethyl-7-(dimethylphenylsilyl)pyrrolizidine

: 301310-42-9
(1R,2R,3R,7S,7aR)-1,2-dibenzyloxy-3-benzyloxymethyl-7-hydroxy-2,3,5,6,7,7a-hexahydro-1H-pyrrolizine

Guidance literature:: With tert.-butylhydroperoxide; tetrabutyl ammonium fluoride; potassium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 40h; Inert atmosphere;
DOI:10.1021/ol203396s

Reference yield: 87.0%

: 1357007-93-2
(1R,2R,3R,7S,7aR)-1,2-bis(benzyloxy)-3-benzyloxymethyl-7-hydroxypyrrolizidin-5-one

: 301310-42-9
(1R,2R,3R,7S,7aR)-1,2-dibenzyloxy-3-benzyloxymethyl-7-hydroxy-2,3,5,6,7,7a-hexahydro-1H-pyrrolizine

Guidance literature:: With borane-dimethyl sulfide complex; In tetrahydrofuran; at 80 ℃; for 1h; Inert atmosphere;
DOI:10.1021/ol203396s

Reference yield:

: (2R,3R,4R,5R)-2-((benzyloxy)methyl)-3,4-bis(benzyloxy)-5-(1-hydroxybut-3-en-1-yl)-N-(tert-butoxycarbonyl)pyrrolidine

: 137741-26-5
(1R,2R,3R,7R,7aR)-1,2-bs(benzyloxy)-3-[(benzyloxy)methyl]hexahydro-1H-pyrrolizin-7-ol

: 301310-42-9
(1R,2R,3R,7S,7aR)-1,2-dibenzyloxy-3-benzyloxymethyl-7-hydroxy-2,3,5,6,7,7a-hexahydro-1H-pyrrolizine

Guidance literature:: (2R,3R,4R,5R)-2-((benzyloxy)methyl)-3,4-bis(benzyloxy)-5-(1-hydroxybut-3-en-1-yl)-N-(tert-butoxycarbonyl)pyrrolidine; With ozone; In methanol; at -60 ℃;

With palladium 10% on activated carbon; hydrogen; acetic acid; In methanol; at 20 ℃; for 24h; under 760.051 Torr; Overall yield = 89 %;
DOI:10.1021/ol503728e