(5S)-7-(tert-butyldiphenylsilyloxy)-5-(tert-butyldimethylsilyloxy)heptan-1-ol

Base Information

Chemical Name:(5S)-7-(tert-butyldiphenylsilyloxy)-5-(tert-butyldimethylsilyloxy)heptan-1-ol
CAS No.:852834-13-0
Molecular Formula:C₂₉H₄₈O₃Si₂
Molecular Weight:500.869
Hs Code.:

Synonyms:(5S)-7-(tert-butyldiphenylsilyloxy)-5-(tert-butyldimethylsilyloxy)heptan-1-ol

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Chemical Property of (5S)-7-(tert-butyldiphenylsilyloxy)-5-(tert-butyldimethylsilyloxy)heptan-1-ol

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Technology Process of (5S)-7-(tert-butyldiphenylsilyloxy)-5-(tert-butyldimethylsilyloxy)heptan-1-ol

There total 3 articles about (5S)-7-(tert-butyldiphenylsilyloxy)-5-(tert-butyldimethylsilyloxy)heptan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 852834-06-1
(3S)-1-(tert-butyldiphenylsilyloxy)-3-(tert-butyldimethylsilyloxy)hept-6-ene

: 852834-13-0
(5S)-7-(tert-butyldiphenylsilyloxy)-5-(tert-butyldimethylsilyloxy)heptan-1-ol

Guidance literature:: (3S)-1-(tert-butyldiphenylsilyloxy)-3-(tert-butyldimethylsilyloxy)hept-6-ene; With dimethylsulfide borane complex; In tetrahydrofuran; at 0 ℃;

With sodium hydroxide; dihydrogen peroxide;
DOI:10.1039/b418106a

Reference yield:

: 1-(tert-butyl-diphenyl-silanyloxy)-hept-6-en-3-ol

: 852834-13-0
(5S)-7-(tert-butyldiphenylsilyloxy)-5-(tert-butyldimethylsilyloxy)heptan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: 98 percent / imidazole; DMAP / CH₂Cl₂

2.1: BH₃*SMe₂ / tetrahydrofuran / 0 °C

2.2: 83 percent / aq. NaOH; H₂O₂

With 1H-imidazole; dmap; dimethylsulfide borane complex; In tetrahydrofuran; dichloromethane;
DOI:10.1039/b418106a

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 852834-13-0
(5S)-7-(tert-butyldiphenylsilyloxy)-5-(tert-butyldimethylsilyloxy)heptan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: 98 percent / imidazole; DMAP / CH₂Cl₂

2.1: BH₃*SMe₂ / tetrahydrofuran / 0 °C

2.2: 83 percent / aq. NaOH; H₂O₂

With 1H-imidazole; dmap; dimethylsulfide borane complex; In tetrahydrofuran; dichloromethane;
DOI:10.1039/b418106a