5'-O-(4,4'-dimethoxytrityl)-2'-O-[1-(2-fluorophenyl)-4-methoxypiperidin-4-yl]-4-O-(2-nitrophenyl)uridine 3'-O-[2-cyanoethyl-N,N-(diisopropylamino)]phosphoramidite

Base Information

Chemical Name:5'-O-(4,4'-dimethoxytrityl)-2'-O-[1-(2-fluorophenyl)-4-methoxypiperidin-4-yl]-4-O-(2-nitrophenyl)uridine 3'-O-[2-cyanoethyl-N,N-(diisopropylamino)]phosphoramidite
CAS No.:861445-26-3
Molecular Formula:C₅₇H₆₄FN₆O₁₂P
Molecular Weight:1075.14
Hs Code.:

5'-O-(4,4'-dimethoxytrityl)-2'-O-[1-(2-fluorophenyl)-4-methoxypiperidin-4-yl]-4-O-(2-nitrophenyl)uridine 3'-O-[2-cyanoethyl-N,N-(diisopropylamino)]phosphoramidite

Synonyms:5'-O-(4,4'-dimethoxytrityl)-2'-O-[1-(2-fluorophenyl)-4-methoxypiperidin-4-yl]-4-O-(2-nitrophenyl)uridine 3'-O-[2-cyanoethyl-N,N-(diisopropylamino)]phosphoramidite

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Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-2'-O-[1-(2-fluorophenyl)-4-methoxypiperidin-4-yl]-4-O-(2-nitrophenyl)uridine 3'-O-[2-cyanoethyl-N,N-(diisopropylamino)]phosphoramidite

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Technology Process of 5'-O-(4,4'-dimethoxytrityl)-2'-O-[1-(2-fluorophenyl)-4-methoxypiperidin-4-yl]-4-O-(2-nitrophenyl)uridine 3'-O-[2-cyanoethyl-N,N-(diisopropylamino)]phosphoramidite

There total 5 articles about 5'-O-(4,4'-dimethoxytrityl)-2'-O-[1-(2-fluorophenyl)-4-methoxypiperidin-4-yl]-4-O-(2-nitrophenyl)uridine 3'-O-[2-cyanoethyl-N,N-(diisopropylamino)]phosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 861445-25-2
5'-O-(4,4'-dimethoxytrityl)-2'-O-[1-(2-fluorophenyl)-4-methoxypiperidin-4-yl]-4-O-(2-nitrophenyl)uridine

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 861445-26-3
5'-O-(4,4'-dimethoxytrityl)-2'-O-[1-(2-fluorophenyl)-4-methoxypiperidin-4-yl]-4-O-(2-nitrophenyl)uridine 3'-O-[2-cyanoethyl-N,N-(diisopropylamino)]phosphoramidite

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1,2-dichloro-ethane; at 0 - 20 ℃;
DOI:10.1081/NCN-200034044

Reference yield:

: 861445-23-0
2'-O-[1-(2-fluorophenyl)-4-methoxypiperidin-4-yl]-4-O-(2-nitrophenyl)uridine

: 861445-26-3
5'-O-(4,4'-dimethoxytrityl)-2'-O-[1-(2-fluorophenyl)-4-methoxypiperidin-4-yl]-4-O-(2-nitrophenyl)uridine 3'-O-[2-cyanoethyl-N,N-(diisopropylamino)]phosphoramidite

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / pyridine / 1.5 h

2: 91 percent / N,N-diisopropylethylamine / 1,2-dichloro-ethane / 0 - 20 °C

With pyridine; N-ethyl-N,N-diisopropylamine; In 1,2-dichloro-ethane;
DOI:10.1081/NCN-200034044

Reference yield:

: 861445-21-8
3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-2'-O-[1-(2-fluorophenyl)-4-methoxypiperidin-4-yl]-4-O-(2-nitrophenyl)uridine

: 861445-26-3
5'-O-(4,4'-dimethoxytrityl)-2'-O-[1-(2-fluorophenyl)-4-methoxypiperidin-4-yl]-4-O-(2-nitrophenyl)uridine 3'-O-[2-cyanoethyl-N,N-(diisopropylamino)]phosphoramidite

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.08 h

2: 89 percent / pyridine / 1.5 h

3: 91 percent / N,N-diisopropylethylamine / 1,2-dichloro-ethane / 0 - 20 °C

With pyridine; tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,2-dichloro-ethane;
DOI:10.1081/NCN-200034044