5'-O-(4,4'-dimethoxytrityl)-2'-O-[1-(2-fluorophenyl)-4-methoxypiperidin-4-yl]-4-O-(2-nitrophenyl)uridine

Base Information

Chemical Name:5'-O-(4,4'-dimethoxytrityl)-2'-O-[1-(2-fluorophenyl)-4-methoxypiperidin-4-yl]-4-O-(2-nitrophenyl)uridine
CAS No.:861445-25-2
Molecular Formula:C₄₈H₄₇FN₄O₁₁
Molecular Weight:874.92
Hs Code.:

Synonyms:5'-O-(4,4'-dimethoxytrityl)-2'-O-[1-(2-fluorophenyl)-4-methoxypiperidin-4-yl]-4-O-(2-nitrophenyl)uridine

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Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-2'-O-[1-(2-fluorophenyl)-4-methoxypiperidin-4-yl]-4-O-(2-nitrophenyl)uridine

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Technology Process of 5'-O-(4,4'-dimethoxytrityl)-2'-O-[1-(2-fluorophenyl)-4-methoxypiperidin-4-yl]-4-O-(2-nitrophenyl)uridine

There total 4 articles about 5'-O-(4,4'-dimethoxytrityl)-2'-O-[1-(2-fluorophenyl)-4-methoxypiperidin-4-yl]-4-O-(2-nitrophenyl)uridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 861445-23-0
2'-O-[1-(2-fluorophenyl)-4-methoxypiperidin-4-yl]-4-O-(2-nitrophenyl)uridine

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 861445-25-2
5'-O-(4,4'-dimethoxytrityl)-2'-O-[1-(2-fluorophenyl)-4-methoxypiperidin-4-yl]-4-O-(2-nitrophenyl)uridine

Guidance literature:: With pyridine; for 1.5h;
DOI:10.1081/NCN-200034044

Reference yield:

: 861445-21-8
3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-2'-O-[1-(2-fluorophenyl)-4-methoxypiperidin-4-yl]-4-O-(2-nitrophenyl)uridine

: 861445-25-2
5'-O-(4,4'-dimethoxytrityl)-2'-O-[1-(2-fluorophenyl)-4-methoxypiperidin-4-yl]-4-O-(2-nitrophenyl)uridine

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.08 h

2: 89 percent / pyridine / 1.5 h

With pyridine; tetrabutyl ammonium fluoride; In tetrahydrofuran;
DOI:10.1081/NCN-200034044

Reference yield:

: 115012-52-7
1-(2-Fluorophenyl)-4-methoxy-1,2,5,6-tetrahydropyridine

: 861445-25-2
5'-O-(4,4'-dimethoxytrityl)-2'-O-[1-(2-fluorophenyl)-4-methoxypiperidin-4-yl]-4-O-(2-nitrophenyl)uridine

Guidance literature:: Multi-step reaction with 3 steps

1: 62 percent / mesitylenesulfonic acid / tetrahydrofuran; acetonitrile

2: 86 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.08 h

3: 89 percent / pyridine / 1.5 h

With pyridine; mesitylene sulfonic acid; tetrabutyl ammonium fluoride; In tetrahydrofuran; acetonitrile;
DOI:10.1081/NCN-200034044