3-(2-Amino-ethylsulfanyl)-2-(2,4-difluoro-phenyl)-3-methyl-1-[1,2,4]triazol-1-yl-butan-2-ol

Base Information

• Chemical Name: 3-(2-Amino-ethylsulfanyl)-2-(2,4-difluoro-phenyl)-3-methyl-1-[1,2,4]triazol-1-yl-butan-2-ol
• CAS No.: 167214-36-0
• Molecular Formula: C₁₅H₂₀F₂N₄OS
• Molecular Weight: 342.413
• Mol file: 167214-36-0.mol

Synonyms:3-(2-Amino-ethylsulfanyl)-2-(2,4-difluoro-phenyl)-3-methyl-1-[1,2,4]triazol-1-yl-butan-2-ol

Chemical Property of 3-(2-Amino-ethylsulfanyl)-2-(2,4-difluoro-phenyl)-3-methyl-1-[1,2,4]triazol-1-yl-butan-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2-Amino-ethylsulfanyl)-2-(2,4-difluoro-phenyl)-3-methyl-1-[1,2,4]triazol-1-yl-butan-2-ol

There total 7 articles about 3-(2-Amino-ethylsulfanyl)-2-(2,4-difluoro-phenyl)-3-methyl-1-[1,2,4]triazol-1-yl-butan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-{2-[2-(2,4-Difluoro-phenyl)-2-hydroxy-1,1-dimethyl-3-[1,2,4]triazol-1-yl-propylsulfanyl]-ethyl}-isoindole-1,3-dione → 3-(2-Amino-ethylsulfanyl)-2-(2,4-difluoro-phenyl)-3-methyl-1-[1,2,4]triazol-1-yl-butan-2-ol (167214-36-0)

Guidance literature:

With hydrazine hydrate; In ethanol; for 20h; Yield given; Ambient temperature;

DOI:10.1248/cpb.44.785

Reference yield:

2-(2,4-Difluoro-phenyl)-3-(2-hydroxy-ethylsulfanyl)-3-methyl-1-[1,2,4]triazol-1-yl-butan-2-ol (167214-29-1) → 3-(2-Amino-ethylsulfanyl)-2-(2,4-difluoro-phenyl)-3-methyl-1-[1,2,4]triazol-1-yl-butan-2-ol (167214-36-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / diethyl azodicarboxylate, Ph₃P / tetrahydrofuran / 20 h / Ambient temperature

2: NH₂NH₂*H₂O / ethanol / 20 h / Ambient temperature

With hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol;

DOI:10.1248/cpb.44.785

Reference yield:

2-bromo-1-(2,4-difluorophenyl)-2-methylpropan-1-one (151856-35-8) → 3-(2-Amino-ethylsulfanyl)-2-(2,4-difluoro-phenyl)-3-methyl-1-[1,2,4]triazol-1-yl-butan-2-ol (167214-36-0)

Guidance literature:

Multi-step reaction with 7 steps

1: 1.) NaH / 1.) DMF, 0 deg C, 2.) DMF, -30 deg C, 1 h

2: 100 percent / pyridinium p-toluenesulfonate / CH₂Cl₂ / 20 h / Ambient temperature

3: 1.) NaH / 1.) DMSO, RT, 30 min, 2.) DMSO, THF, RT, 24 h

4: NaOH / dimethylsulfoxide / a) 80 deg C, 3 h, b) 100 deg C, 1 h

5: 75 percent / p-TsOH*H₂O, MeOH / 20 h / Ambient temperature

6: 65 percent / diethyl azodicarboxylate, Ph₃P / tetrahydrofuran / 20 h / Ambient temperature

7: NH₂NH₂*H₂O / ethanol / 20 h / Ambient temperature

With methanol; sodium hydroxide; pyridinium p-toluenesulfonate; sodium hydride; toluene-4-sulfonic acid; hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide;

DOI:10.1248/cpb.44.785

upstream raw materials:

2-(2,4-Difluoro-phenyl)-3-(2-hydroxy-ethylsulfanyl)-3-methyl-1-[1,2,4]triazol-1-yl-butan-2-ol

2-bromo-1-(2,4-difluorophenyl)-2-methylpropan-1-one

1-(2,4-Difluoro-phenyl)-2-(2-hydroxy-ethylsulfanyl)-2-methyl-propan-1-one

1-(2,4-Difluoro-phenyl)-2-methyl-2-[2-(tetrahydro-pyran-2-yloxy)-ethylsulfanyl]-propan-1-one