1-(2,4-Difluoro-phenyl)-2-(2-hydroxy-ethylsulfanyl)-2-methyl-propan-1-one

Base Information

Chemical Name:1-(2,4-Difluoro-phenyl)-2-(2-hydroxy-ethylsulfanyl)-2-methyl-propan-1-one
CAS No.:167214-88-2
Molecular Formula:C₁₂H₁₄F₂O₂S
Molecular Weight:260.305
Hs Code.:

Synonyms:1-(2,4-Difluoro-phenyl)-2-(2-hydroxy-ethylsulfanyl)-2-methyl-propan-1-one

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Chemical Property of 1-(2,4-Difluoro-phenyl)-2-(2-hydroxy-ethylsulfanyl)-2-methyl-propan-1-one

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Technology Process of 1-(2,4-Difluoro-phenyl)-2-(2-hydroxy-ethylsulfanyl)-2-methyl-propan-1-one

There total 1 articles about 1-(2,4-Difluoro-phenyl)-2-(2-hydroxy-ethylsulfanyl)-2-methyl-propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 151856-35-8
2-bromo-1-(2,4-difluorophenyl)-2-methylpropan-1-one

: 60-24-2
2-hydroxyethanethiol

: 167214-88-2
1-(2,4-Difluoro-phenyl)-2-(2-hydroxy-ethylsulfanyl)-2-methyl-propan-1-one

Guidance literature:: With sodium hydride; Yield given. Multistep reaction; 1.) DMF, 0 deg C, 2.) DMF, -30 deg C, 1 h;
DOI:10.1248/cpb.44.785

Reference yield: 100.0%

: 110-87-2
3,4-dihydro-2H-pyran

: 167214-88-2
1-(2,4-Difluoro-phenyl)-2-(2-hydroxy-ethylsulfanyl)-2-methyl-propan-1-one

: 167214-89-3
1-(2,4-Difluoro-phenyl)-2-methyl-2-[2-(tetrahydro-pyran-2-yloxy)-ethylsulfanyl]-propan-1-one

Guidance literature:: With pyridinium p-toluenesulfonate; In dichloromethane; for 20h; Ambient temperature;
DOI:10.1248/cpb.44.785

Reference yield:

: 167214-88-2
1-(2,4-Difluoro-phenyl)-2-(2-hydroxy-ethylsulfanyl)-2-methyl-propan-1-one

: 167214-36-0
3-(2-Amino-ethylsulfanyl)-2-(2,4-difluoro-phenyl)-3-methyl-1-[1,2,4]triazol-1-yl-butan-2-ol

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / pyridinium p-toluenesulfonate / CH₂Cl₂ / 20 h / Ambient temperature

2: 1.) NaH / 1.) DMSO, RT, 30 min, 2.) DMSO, THF, RT, 24 h

3: NaOH / dimethylsulfoxide / a) 80 deg C, 3 h, b) 100 deg C, 1 h

4: 75 percent / p-TsOH*H₂O, MeOH / 20 h / Ambient temperature

5: 65 percent / diethyl azodicarboxylate, Ph₃P / tetrahydrofuran / 20 h / Ambient temperature

6: NH₂NH₂*H₂O / ethanol / 20 h / Ambient temperature

With methanol; sodium hydroxide; pyridinium p-toluenesulfonate; sodium hydride; toluene-4-sulfonic acid; hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1248/cpb.44.785