1-{4'-[3-((R)-1-phenyl-ethoxycarbonylamino)-[1,2,4]triazol-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid

Base Information

Chemical Name:1-{4'-[3-((R)-1-phenyl-ethoxycarbonylamino)-[1,2,4]triazol-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid
CAS No.:1396007-61-6
Molecular Formula:C₂₇H₂₄N₄O₄
Molecular Weight:468.512
Hs Code.:

Synonyms:1-{4'-[3-((R)-1-phenyl-ethoxycarbonylamino)-[1,2,4]triazol-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid

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Chemical Property of 1-{4'-[3-((R)-1-phenyl-ethoxycarbonylamino)-[1,2,4]triazol-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid

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Technology Process of 1-{4'-[3-((R)-1-phenyl-ethoxycarbonylamino)-[1,2,4]triazol-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid

There total 7 articles about 1-{4'-[3-((R)-1-phenyl-ethoxycarbonylamino)-[1,2,4]triazol-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1396007-99-0
1-{4'-[3-((R)-1-phenyl-ethoxycarbonylamino)-[1,2,4]triazol-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid methyl ester

: 1396007-61-6
1-{4'-[3-((R)-1-phenyl-ethoxycarbonylamino)-[1,2,4]triazol-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; methanol; at 25 ℃; for 17h;

Reference yield:

: 1517-69-7
(R)-1-phenylethanol

: 1396007-61-6
1-{4'-[3-((R)-1-phenyl-ethoxycarbonylamino)-[1,2,4]triazol-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethyl acetate / 20 h / Reflux; Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / 25 °C / Inert atmosphere

2.2: 0.25 h / 25 °C

3.1: water; lithium hydroxide / methanol; tetrahydrofuran / 17 h / 25 °C

With water; lithium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; ethyl acetate;

Reference yield:

: 30895-20-6
1-(4-bromophenyl)-2-methyl-isothiourea hydroiodide

: 1396007-61-6
1-{4'-[3-((R)-1-phenyl-ethoxycarbonylamino)-[1,2,4]triazol-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrazine hydrate / water; ethanol / 20 h / 25 °C

2.1: 3.5 h / 120 °C

3.1: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,4-dioxane / 24 h / 100 °C / Inert atmosphere

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / 25 °C / Inert atmosphere

4.2: 0.25 h / 25 °C

5.1: water; lithium hydroxide / methanol; tetrahydrofuran / 17 h / 25 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; water; sodium carbonate; hydrazine hydrate; lithium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; 3.1: |Suzuki Coupling;