1-{4'-[3-((R)-1-phenyl-ethoxycarbonylamino)-[1,2,4]triazol-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid methyl ester

Base Information

Chemical Name:1-{4'-[3-((R)-1-phenyl-ethoxycarbonylamino)-[1,2,4]triazol-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid methyl ester
CAS No.:1396007-99-0
Molecular Formula:C₂₈H₂₆N₄O₄
Molecular Weight:482.539
Hs Code.:

Synonyms:1-{4'-[3-((R)-1-phenyl-ethoxycarbonylamino)-[1,2,4]triazol-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid methyl ester

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Chemical Property of 1-{4'-[3-((R)-1-phenyl-ethoxycarbonylamino)-[1,2,4]triazol-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid methyl ester

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Technology Process of 1-{4'-[3-((R)-1-phenyl-ethoxycarbonylamino)-[1,2,4]triazol-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid methyl ester

There total 6 articles about 1-{4'-[3-((R)-1-phenyl-ethoxycarbonylamino)-[1,2,4]triazol-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1247028-03-0
(R)-1-phenylethyl 1H-imidazole-1-carboxylate

: 1396007-98-9
1-[4'-(3-amino-[1,2,4]triazol-4-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid methyl ester

: 1396007-99-0
1-{4'-[3-((R)-1-phenyl-ethoxycarbonylamino)-[1,2,4]triazol-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid methyl ester

Guidance literature:: 1-[4'-(3-amino-[1,2,4]triazol-4-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid methyl ester; With lithium hexamethyldisilazane; In tetrahydrofuran; at 25 ℃; for 0.25h; Inert atmosphere;

(R)-1-phenylethyl 1H-imidazole-1-carboxylate; In tetrahydrofuran; at 25 ℃; for 0.25h;

Reference yield:

: 1517-69-7
(R)-1-phenylethanol

: 1396007-99-0
1-{4'-[3-((R)-1-phenyl-ethoxycarbonylamino)-[1,2,4]triazol-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethyl acetate / 20 h / Reflux; Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / 25 °C / Inert atmosphere

2.2: 0.25 h / 25 °C

With lithium hexamethyldisilazane; In tetrahydrofuran; ethyl acetate;

Reference yield:

: 2646-30-2
1-(4-bromophenyl)thiourea

: 1396007-99-0
1-{4'-[3-((R)-1-phenyl-ethoxycarbonylamino)-[1,2,4]triazol-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: methanol / 17 h / 25 °C

2.1: hydrazine hydrate / water; ethanol / 20 h / 25 °C

3.1: 3.5 h / 120 °C

4.1: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,4-dioxane / 24 h / 100 °C / Inert atmosphere

5.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / 25 °C / Inert atmosphere

5.2: 0.25 h / 25 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; hydrazine hydrate; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; 4.1: |Suzuki Coupling;