Technology Process of 1-{4'-[3-((R)-1-phenyl-ethoxycarbonylamino)-[1,2,4]triazol-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid methyl ester
There total 6 articles about 1-{4'-[3-((R)-1-phenyl-ethoxycarbonylamino)-[1,2,4]triazol-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1-[4'-(3-amino-[1,2,4]triazol-4-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid methyl ester;
With
lithium hexamethyldisilazane;
In
tetrahydrofuran;
at 25 ℃;
for 0.25h;
Inert atmosphere;
(R)-1-phenylethyl 1H-imidazole-1-carboxylate;
In
tetrahydrofuran;
at 25 ℃;
for 0.25h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: ethyl acetate / 20 h / Reflux; Inert atmosphere
2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / 25 °C / Inert atmosphere
2.2: 0.25 h / 25 °C
With
lithium hexamethyldisilazane;
In
tetrahydrofuran; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: methanol / 17 h / 25 °C
2.1: hydrazine hydrate / water; ethanol / 20 h / 25 °C
3.1: 3.5 h / 120 °C
4.1: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,4-dioxane / 24 h / 100 °C / Inert atmosphere
5.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / 25 °C / Inert atmosphere
5.2: 0.25 h / 25 °C
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; hydrazine hydrate; lithium hexamethyldisilazane;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water;
4.1: |Suzuki Coupling;
