2,2,2-trichloroethyl (6R,7R,2'R)-7-(2'-azido-2'-phenylacetamido)-3-methylceph-3-em-4-carboxylate

Base Information

Chemical Name:2,2,2-trichloroethyl (6R,7R,2'R)-7-(2'-azido-2'-phenylacetamido)-3-methylceph-3-em-4-carboxylate
CAS No.:38015-94-0
Molecular Formula:C₁₈H₁₆Cl₃N₅O₄S
Molecular Weight:504.781
Hs Code.:

Synonyms:2,2,2-trichloroethyl (6R,7R,2'R)-7-(2'-azido-2'-phenylacetamido)-3-methylceph-3-em-4-carboxylate

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Chemical Property of 2,2,2-trichloroethyl (6R,7R,2'R)-7-(2'-azido-2'-phenylacetamido)-3-methylceph-3-em-4-carboxylate

Chemical Property:

Purity/Quality:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2,2,2-trichloroethyl (6R,7R,2'R)-7-(2'-azido-2'-phenylacetamido)-3-methylceph-3-em-4-carboxylate

There total 3 articles about 2,2,2-trichloroethyl (6R,7R,2'R)-7-(2'-azido-2'-phenylacetamido)-3-methylceph-3-em-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 38015-90-6
2,2,2-trichloroethyl (1S,3S,5R,6R,2'R)-6-(2'-azido-2'-phenylacetamido)-2,2-dimethylpenam-3-carboxylate, 1-oxide

: 38015-94-0
2,2,2-trichloroethyl (6R,7R,2'R)-7-(2'-azido-2'-phenylacetamido)-3-methylceph-3-em-4-carboxylate

Guidance literature:: With dichloromethanephosphonic acid mono-pyridinium salt; In 1,4-dioxane; for 10h; Heating;
DOI:10.1016/0040-4020(84)85096-6

Reference yield:

: 39879-59-9
2,2,2-trichloroethyl (1S,3S,5R,6R)-6-phenylacetamido-2,2-dimethylpenam-3-carboxylate, 1-oxide

: 38015-94-0
2,2,2-trichloroethyl (6R,7R,2'R)-7-(2'-azido-2'-phenylacetamido)-3-methylceph-3-em-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 31.7 percent / 1,3-dibromo-5,5-dimethylhydantoin, propylene oxide / 1,2-dichloro-ethane / -15 °C / Irradiation

2: 58 percent / NaN₃ / dimethylformamide / 0.5 h

3: 86 percent / dichloromethanephosphonic acid mono-pyridinium salt / dioxane / 10 h / Heating

With sodium azide; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; dichloromethanephosphonic acid mono-pyridinium salt; methyloxirane; In 1,4-dioxane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/0040-4020(84)85096-6

Reference yield:

: 38015-83-7
2,2,2-trichloroethyl (1S,3S,5R,6R,2'S)-6-(2'-bromo-2'-phenylacetamido)-2,2-dimethylpenam-3-carboxylate, 1-oxide

: 38015-94-0
2,2,2-trichloroethyl (6R,7R,2'R)-7-(2'-azido-2'-phenylacetamido)-3-methylceph-3-em-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 58 percent / NaN₃ / dimethylformamide / 0.5 h

2: 86 percent / dichloromethanephosphonic acid mono-pyridinium salt / dioxane / 10 h / Heating

With sodium azide; dichloromethanephosphonic acid mono-pyridinium salt; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1016/0040-4020(84)85096-6