Chemical Property of CID 6560168
Chemical Property:
- Appearance/Colour:white crystalline powder
- Vapor Pressure:3.27E-22mmHg at 25°C
- Melting Point:196-198 °C
- Refractive Index:1.6320 (estimate)
- Boiling Point:727.4°C at760mmHg
- PKA:5.2, 7.3(at 25℃)
- Flash Point:393.7°C
- PSA：138.03000
- Density:1.5 g/cm3
- LogP:1.47400
- Storage Temp.:2-8°C
- Solubility.:NH4OH 1 M: 50 mg/mL, clear, yellow
- Water Solubility.:微溶于水，不溶于乙醇、氯仿、乙醚。
- XLogP3:1.3
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:3
- Exact Mass:347.09397721
- Heavy Atom Count:24
- Complexity:595
- Purity/Quality:
-
99%, *data from raw suppliers
Cefalexin
VETRANAL *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xn
- Hazard Codes:Xn
- Statements:
42/43
- Safety Statements:
22-36/37-45
- MSDS Files:
-
SDS file from LookChem
Total 1 MSDS from other Authors
Useful:
- Canonical SMILES:CC1=C(N2C(C(C2=O)NC(=O)C(C3=CC=CC=C3)[NH3+])SC1)C(=O)[O-]
- Isomeric SMILES:CC1=C(N2[C@@H]([C@@H](C2=O)NC(=O)[C@@H](C3=CC=CC=C3)[NH3+])SC1)C(=O)[O-]
-
Description
Cephalexin is a cephalosporin antibiotic that is used to examine the impact of binding, expression, and inhibition of PBP3 as well as additional penicillin-binding proteins (PBPs) on the cell wall during bacterial mucopeptide synthesis. Cephalexin is used for the treatment of infection-causing bacteria that may induce ear, respiratory, urinary tract, and skin infections. Bacteria that are defenseless against Cephalexin may include Streptococcus pneumonia, Staphylococcus aureus, E. coli, and Haemophilus influenza. Cephalexin is also referred to as Keflex (brand name), and it does not relieve viral infections such as flu or colds. Use of the ampicillin-type side chain conveys oral activity to cephalexin. Whereas it no longer has an
activating side chain at C-3 and, as a consequence, is somewhat less potent, it does not undergo metabolic
deactivation and, thus, maintains potency. It is rapidly and completely absorbed from the GI tract and has
become quite popular. Somewhat puzzling is the fact that the use of the ampicillin side chain in the
cephalosporins does not result in a comparable shift in antimicrobial spectrum. Cephalexin, like the other
first-generation cephalosporins is active against many Gram-positive aerobic cocci but is limited against
Gram-negative bacteria. It is a widely used drug, particularly against Gram-negative bacteria causing urinary
tract infections, Gram-positive infections (Staphyl ococcus aureus, Streptococcus pneumoni ae and
Streptococcus pyogenes) of soft tissues, pharyngitis, and minor wounds.
-
Indications
Cephalexin is prescribed for the treatment of otitis media, genitourinary, bone, respiratory, and skin structure infections.
-
Uses
Cephalexin is administered to minimize the development of bacteria that are resistant to drugs. To maintain the overall effectiveness of Cephalexin, the drug should be prescribed as a treatment for infections that can be attributed to bacteria. The availability of susceptibility and culture information should be put into consideration while making modifications to antibacterial therapy. The absence of such information may be backed by susceptibility and epidemiology patterns to influence verifiable adoption of treatment.
In some cases, Cephalexin is used for the treatment of patients who are allergic to penicillin and may have a heart condition at the time when they are undergoing a procedure on their respiratory tract, to inhibit the development of infection on their heart valves. Antibacterial.
-
Therapeutic Function
Antibiotic
-
Clinical Use
Cephalexin, 7α-(D-amino-α-phenylacetamido)-3-methylcephemcarboxylicacid (Keflex, Keforal), was designed purposelyas an orally active, semisynthetic cephalosporin. Theoral inactivation of cephalosporins has been attributed to twocauses: instability of the β-lactam ring to acid hydrolysis(cephalothin and cephaloridine) and solvolysis or microbialtransformation of the 3-methylacetoxy group (cephalothin,cephaloglycin). The α-amino group of cephalexin renders itacid stable, and reduction of the 3-acetoxymethyl to a methylgroup circumvents reaction at that site.Cephalexin occurs as a white crystalline monohydrate. Itis freely soluble in water, resistant to acid, and absorbed wellorally. Food does not interfere with its absorption. Becauseof minimal protein binding and nearly exclusive renal excretion,cephalexin is recommended particularly for the treatmentof urinary tract infections. It is also sometimes used forupper respiratory tract infections. Its spectrum of activity isvery similar to those of cephalothin and cephaloridine.Cephalexin is somewhat less potent than these two agentsafter parenteral administration and, therefore, is inferior tothem for the treatment of serious systemic infections. As for group 2 cephalosporins . It should not be used
in infections in which H. influenzae is, or is likely to be, implicated.
It should not be used as an alternative to penicillin in
syphilis.
-
Drug interactions
Potentially hazardous interactions with other drugs
Anticoagulants: effects of coumarins may be
enhanced.
