1-[(2R,5S)-3-fluoro-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione

Base Information

Chemical Name:1-[(2R,5S)-3-fluoro-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione
CAS No.:122757-52-2
Molecular Formula:C₉H₉FN₂O₄
Molecular Weight:228.18
Hs Code.:
Mol file:122757-52-2.mol

Synonyms:Uridine,2',3'-didehydro-2'-fluoro- (9CI)

Suppliers and Price of 1-[(2R,5S)-3-fluoro-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 1-[(2R,5S)-3-fluoro-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione

Chemical Property:

Density:1.57g/cm³

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-[(2R,5S)-3-fluoro-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione

There total 8 articles about 1-[(2R,5S)-3-fluoro-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 128496-13-9
2',3'-dideoxy-2',3'-didehydro-3'-fluoro-5'-O-trityluridine

: 122757-52-2
2',3'-dideoxy-2',3'-didehydro-3'-fluorouridine

Guidance literature:: With hydrogenchloride; In chloroform; at 0 ℃; for 0.5h;
DOI:10.1021/jm00170a015

Reference yield:

: 1-[(2R,5S)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-3-fluoro-2,5-dihydro-furan-2-yl]-1H-pyrimidine-2,4-dione

: 122757-52-2
2',3'-dideoxy-2',3'-didehydro-3'-fluorouridine

Guidance literature:: With ammonium fluoride; In methanol; for 2h; Heating;
DOI:10.1021/ja962117m

Reference yield:

: Thiocarbonic acid O-[(2R,3R,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-4-methanesulfonyl-tetrahydro-furan-3-yl] ester O-phenyl ester

: 122757-52-2
2',3'-dideoxy-2',3'-didehydro-3'-fluorouridine

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / Bu₃SnH, AIBN / toluene / 2.5 h / 115 °C

2: NH₄F / methanol / 2 h / Heating

With ammonium fluoride; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In methanol; toluene;
DOI:10.1021/ja962117m