3-[6-bromo-2-fluoro-3-(1H-pyrazolo[3,4-b]pyridin-3-ylmethyl)phenoxy]-5-cholorobenzonitrile

Base Information

• Chemical Name: 3-[6-bromo-2-fluoro-3-(1H-pyrazolo[3,4-b]pyridin-3-ylmethyl)phenoxy]-5-cholorobenzonitrile
• CAS No.: 1007570-78-6
• Molecular Formula: C₂₀H₁₁BrClFN₄O
• Molecular Weight: 457.689

Synonyms:3-[6-bromo-2-fluoro-3-(1H-pyrazolo[3,4-b]pyridin-3-ylmethyl)phenoxy]-5-cholorobenzonitrile

Chemical Property of 3-[6-bromo-2-fluoro-3-(1H-pyrazolo[3,4-b]pyridin-3-ylmethyl)phenoxy]-5-cholorobenzonitrile

Chemical Property:

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Technology Process of 3-[6-bromo-2-fluoro-3-(1H-pyrazolo[3,4-b]pyridin-3-ylmethyl)phenoxy]-5-cholorobenzonitrile

There total 1 articles about 3-[6-bromo-2-fluoro-3-(1H-pyrazolo[3,4-b]pyridin-3-ylmethyl)phenoxy]-5-cholorobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

3-(6-bromo-3-{2-[2-(2,4-difluorophenoxy)pyridin-3-yl]-2-oxoethyl}-2-fluorophenoxy)-5-cholorobenzonitrile (1007571-53-0) → 3-[6-bromo-2-fluoro-3-(1H-pyrazolo[3,4-b]pyridin-3-ylmethyl)phenoxy]-5-cholorobenzonitrile (1007570-78-6)

Guidance literature:

With hydrazine; In 1,4-dioxane; ethanol; at 100 ℃; for 2h; Product distribution / selectivity;

Reference yield: 85.0%

3-[6-bromo-2-fluoro-3-(1H-pyrazolo[3,4-b]pyridin-3-ylmethyl)phenoxy]-5-cholorobenzonitrile (1007570-78-6) → 3-[6-bromo-2-fluoro-3-(7-oxy-1H-pyrazolo[3,4-b]pyridin-3-ylmethyl)-phenoxy]-5-chloro-benzonitrile (1007570-79-7)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; Product distribution / selectivity;

Reference yield: 53.0%

3-[6-bromo-2-fluoro-3-(1H-pyrazolo[3,4-b]pyridin-3-ylmethyl)phenoxy]-5-cholorobenzonitrile (1007570-78-6) + methyl iodide (74-88-4) → 3-[6-bromo-2-fluoro-3-(1-methyl-1H-pyrazolo[3,4-b]pyridin-3-ylmethyl)-phenoxy]-5-chloro-benzonitrile

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 17h;

upstream raw materials:

3-(6-bromo-3-{2-[2-(2,4-difluorophenoxy)pyridin-3-yl]-2-oxoethyl}-2-fluorophenoxy)-5-cholorobenzonitrile

Downstream raw materials:

3-[6-bromo-2-fluoro-3-(7-oxy-1H-pyrazolo[3,4-b]pyridin-3-ylmethyl)-phenoxy]-5-chloro-benzonitrile

C₂₉H₂₇BrClFN₆O₄

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