2-[3-(6-chloro-pyridin-3-yl)-phenyl]-9-(4-methoxy-phenyl)-[1,10]phenanthroline

Base Information

Chemical Name:2-[3-(6-chloro-pyridin-3-yl)-phenyl]-9-(4-methoxy-phenyl)-[1,10]phenanthroline
CAS No.:350489-41-7
Molecular Formula:C₃₀H₂₀ClN₃O
Molecular Weight:473.961
Hs Code.:

Synonyms:2-[3-(6-chloro-pyridin-3-yl)-phenyl]-9-(4-methoxy-phenyl)-[1,10]phenanthroline

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Chemical Property of 2-[3-(6-chloro-pyridin-3-yl)-phenyl]-9-(4-methoxy-phenyl)-[1,10]phenanthroline

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Technology Process of 2-[3-(6-chloro-pyridin-3-yl)-phenyl]-9-(4-methoxy-phenyl)-[1,10]phenanthroline

There total 4 articles about 2-[3-(6-chloro-pyridin-3-yl)-phenyl]-9-(4-methoxy-phenyl)-[1,10]phenanthroline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 350489-38-2
2-chloro-5-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl)-pyridine

: 2-(3-bromo-phenyl)-9-(4-methoxy-phenyl)-[1,10]phenanthroline

: 350489-41-7
2-[3-(6-chloro-pyridin-3-yl)-phenyl]-9-(4-methoxy-phenyl)-[1,10]phenanthroline

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In toluene; at 110 ℃; for 7h;
DOI:10.1016/S0040-4039(01)00279-9

Reference yield:

: 1072-97-5
5-bromo-2-pyridylamine

: 350489-41-7
2-[3-(6-chloro-pyridin-3-yl)-phenyl]-9-(4-methoxy-phenyl)-[1,10]phenanthroline

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaNO₂ / aq. HCl / -5 - 0 °C

1.2: 40 percent / CuCl / 20 °C

2.1: butyllithium / diethyl ether / 6 h / -78 °C

2.2: diethyl ether / 12 h / -78 - 20 °C

3.1: diethyl ether / 1 h / 0 °C

3.2: methanesulfonic acid / diethyl ether / 0.5 h / 0 °C

4.1: 55 percent / Pd[P(C₆H₅)3]4; aq. Na₂CO₃ / toluene / 7 h / 110 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; sodium carbonate; sodium nitrite; In hydrogenchloride; diethyl ether; toluene; 4.1: Suzuki cross-coupling;
DOI:10.1016/S0040-4039(01)00279-9

Reference yield:

: 53939-30-3
5-bromo-2-chloropyridine

: 350489-41-7
2-[3-(6-chloro-pyridin-3-yl)-phenyl]-9-(4-methoxy-phenyl)-[1,10]phenanthroline

Guidance literature:: Multi-step reaction with 3 steps

1.1: butyllithium / diethyl ether / 6 h / -78 °C

1.2: diethyl ether / 12 h / -78 - 20 °C

2.1: diethyl ether / 1 h / 0 °C

2.2: methanesulfonic acid / diethyl ether / 0.5 h / 0 °C

3.1: 55 percent / Pd[P(C₆H₅)3]4; aq. Na₂CO₃ / toluene / 7 h / 110 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; sodium carbonate; In diethyl ether; toluene; 3.1: Suzuki cross-coupling;
DOI:10.1016/S0040-4039(01)00279-9