Acetic acid 2-((4aR,4bS,5R,6aS,6bS,9aR,10aS,10bS,12S)-12-fluoro-5-hydroxy-4a,6a,8,8-tetramethyl-2-oxo-2,3,4,4a,4b,5,6,6a,9a,10,10a,10b,11,12-tetradecahydro-7,9-dioxa-pentaleno[2,1-a]phenanthren-6b-yl)-2-oxo-ethyl ester

Base Information

• Chemical Name: Acetic acid 2-((4aR,4bS,5R,6aS,6bS,9aR,10aS,10bS,12S)-12-fluoro-5-hydroxy-4a,6a,8,8-tetramethyl-2-oxo-2,3,4,4a,4b,5,6,6a,9a,10,10a,10b,11,12-tetradecahydro-7,9-dioxa-pentaleno[2,1-a]phenanthren-6b-yl)-2-oxo-ethyl ester
• CAS No.: 3900-35-4
• Molecular Formula: C₂₆H₃₅FO₇
• Molecular Weight: 478.558

Synonyms:Acetic acid 2-((4aR,4bS,5R,6aS,6bS,9aR,10aS,10bS,12S)-12-fluoro-5-hydroxy-4a,6a,8,8-tetramethyl-2-oxo-2,3,4,4a,4b,5,6,6a,9a,10,10a,10b,11,12-tetradecahydro-7,9-dioxa-pentaleno[2,1-a]phenanthren-6b-yl)-2-oxo-ethyl ester

Chemical Property of Acetic acid 2-((4aR,4bS,5R,6aS,6bS,9aR,10aS,10bS,12S)-12-fluoro-5-hydroxy-4a,6a,8,8-tetramethyl-2-oxo-2,3,4,4a,4b,5,6,6a,9a,10,10a,10b,11,12-tetradecahydro-7,9-dioxa-pentaleno[2,1-a]phenanthren-6b-yl)-2-oxo-ethyl ester

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Technology Process of Acetic acid 2-((4aR,4bS,5R,6aS,6bS,9aR,10aS,10bS,12S)-12-fluoro-5-hydroxy-4a,6a,8,8-tetramethyl-2-oxo-2,3,4,4a,4b,5,6,6a,9a,10,10a,10b,11,12-tetradecahydro-7,9-dioxa-pentaleno[2,1-a]phenanthren-6b-yl)-2-oxo-ethyl ester

There total 3 articles about Acetic acid 2-((4aR,4bS,5R,6aS,6bS,9aR,10aS,10bS,12S)-12-fluoro-5-hydroxy-4a,6a,8,8-tetramethyl-2-oxo-2,3,4,4a,4b,5,6,6a,9a,10,10a,10b,11,12-tetradecahydro-7,9-dioxa-pentaleno[2,1-a]phenanthren-6b-yl)-2-oxo-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6α-Fluoro-21-hydroxy-16α,17α-isopropenylidenedioxypregn-4-ene-3,20-dione (1526-01-8) + acetic anhydride (108-24-7) → Acetic acid 2-((4aR,4bS,5R,6aS,6bS,9aR,10aS,10bS,12S)-12-fluoro-5-hydroxy-4a,6a,8,8-tetramethyl-2-oxo-2,3,4,4a,4b,5,6,6a,9a,10,10a,10b,11,12-tetradecahydro-7,9-dioxa-pentaleno[2,1-a]phenanthren-6b-yl)-2-oxo-ethyl ester (3900-35-4) + 21-acetoxy-6α-fluoro-11β-hydroxy-16α,17-isopropylidenedioxy-pregn-4-ene-3,20-dione (2802-11-1)

Guidance literature:

With barium(II) acetate; Yield given. Multistep reaction. Yields of byproduct given; 1.) culture of blakesleeana Cumminghamella, 2.) glacial acetic acid, 24 h;

DOI:10.1007/BF01152334

Reference yield:

6α-Fluoro-21-hydroxy-16α,17α-isopropenylidenedioxypregn-4-ene-3,20-dione (1526-01-8) + acetic acid (64-19-7,77671-22-8) → Acetic acid 2-((4aR,4bS,5R,6aS,6bS,9aR,10aS,10bS,12S)-12-fluoro-5-hydroxy-4a,6a,8,8-tetramethyl-2-oxo-2,3,4,4a,4b,5,6,6a,9a,10,10a,10b,11,12-tetradecahydro-7,9-dioxa-pentaleno[2,1-a]phenanthren-6b-yl)-2-oxo-ethyl ester (3900-35-4) + 21-acetoxy-6α-fluoro-11β-hydroxy-16α,17-isopropylidenedioxy-pregn-4-ene-3,20-dione (2802-11-1)

Guidance literature:

With barium(II) acetate; Yield given. Multistep reaction. Yields of byproduct given; 1.) culture of Tieghemella orchidis, 2.) room temp., 20 h;

DOI:10.1007/BF01152334

Reference yield:

→ 6α-Fluor-16α-hydroxy-21-O-acetyl-hydrocortison-16,17-acetonid (2802-11-1,3900-35-4)

Guidance literature:

aus 6α-Fluor-16α-hydroxy-hydrocortison, 1) Acn. , 2) + Acetanhydrid - Py.;

DOI:10.1021/ja01498a041

upstream raw materials:

6α-Fluoro-21-hydroxy-16α,17α-isopropenylidenedioxypregn-4-ene-3,20-dione

acetic anhydride

acetic acid

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