2-<8-(dimethoxyphosphoryl)-1-oxo-3-phenyl-1,2-dihydropyrido<3,4-b>indol-2-yl>-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide

Base Information

• Chemical Name: 2-<8-(dimethoxyphosphoryl)-1-oxo-3-phenyl-1,2-dihydropyrido<3,4-b>indol-2-yl>-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide
• CAS No.: 161488-63-7
• Molecular Formula: C₂₇H₂₉F₃N₃O₆P
• Molecular Weight: 579.513
• Mol file: 161488-63-7.mol

Synonyms:2-<8-(dimethoxyphosphoryl)-1-oxo-3-phenyl-1,2-dihydropyrido<3,4-b>indol-2-yl>-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide

Chemical Property of 2-<8-(dimethoxyphosphoryl)-1-oxo-3-phenyl-1,2-dihydropyrido<3,4-b>indol-2-yl>-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-<8-(dimethoxyphosphoryl)-1-oxo-3-phenyl-1,2-dihydropyrido<3,4-b>indol-2-yl>-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide

There total 20 articles about 2-<8-(dimethoxyphosphoryl)-1-oxo-3-phenyl-1,2-dihydropyrido<3,4-b>indol-2-yl>-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

{9-Benzyl-1-oxo-3-phenyl-2-[(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-methyl]-2,9-dihydro-1H-β-carbolin-8-yl}-phosphonic acid dimethyl ester (1026494-28-9) → 2-<8-(dimethoxyphosphoryl)-1-oxo-3-phenyl-1,2-dihydropyrido<3,4-b>indol-2-yl>-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide (161488-63-7)

Guidance literature:

With aluminium trichloride; nitromethane; In benzene; for 6h;

DOI:10.1021/jm00001a014

Reference yield:

3(RS)-amino-1,1,1-trifluoro-2(RS)-hydroxy-4-methylpentane hydrochloride (106746-09-2) → 2-<8-(dimethoxyphosphoryl)-1-oxo-3-phenyl-1,2-dihydropyrido<3,4-b>indol-2-yl>-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide (161488-63-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 1-hydroxybenzotriazole, triethylamine, 1-<3-(dimethylamino)propyl>-3-ethylcarbodimide / dimethylformamide

2: 1.18 g / triethylamine / CH₂Cl₂ / 12 h

3: 0.41 g / N-methylmorpholine, tetrakis(triphenylphosphine)palladium(O) / acetonitrile / 24 h / 80 °C

4: 21 percent / nitromethane, aluminum chloride / benzene / 6 h

With 4-methyl-morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; aluminium trichloride; nitromethane; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In dichloromethane; N,N-dimethyl-formamide; acetonitrile; benzene;

DOI:10.1021/jm00001a014

Reference yield:

(8,9-Dibenzyl-1-oxo-3-phenyl-1,9-dihydro-β-carbolin-2-yl)-acetic acid → 2-<8-(dimethoxyphosphoryl)-1-oxo-3-phenyl-1,2-dihydropyrido<3,4-b>indol-2-yl>-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide (161488-63-7)

Guidance literature:

Multi-step reaction with 5 steps

1: EDC, Et₃N / dimethylformamide

2: 1.6 g / H₂ / 10percent Pd/C / ethanol

3: 1.18 g / triethylamine / CH₂Cl₂ / 12 h

4: 0.41 g / N-methylmorpholine, tetrakis(triphenylphosphine)palladium(O) / acetonitrile / 24 h / 80 °C

5: 21 percent / nitromethane, aluminum chloride / benzene / 6 h

With 4-methyl-morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; aluminium trichloride; nitromethane; hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile; benzene;

DOI:10.1021/jm00001a014

upstream raw materials:

{9-Benzyl-1-oxo-3-phenyl-2-[(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-methyl]-2,9-dihydro-1H-β-carbolin-8-yl}-phosphonic acid dimethyl ester

2,2-diethoxyacetophenone

3(RS)-amino-1,1,1-trifluoro-2(RS)-hydroxy-4-methylpentane hydrochloride

N-allyl-2,2-diethoxy-1-phenylethylamine