(+)-(1'S,2'S,2S,3S)-3-tert-butyl-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-2,N-dimethylheptanamide

Base Information

• Chemical Name: (+)-(1'S,2'S,2S,3S)-3-tert-butyl-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-2,N-dimethylheptanamide
• CAS No.: 897920-56-8
• Molecular Formula: C₂₂H₃₇NO₂
• Molecular Weight: 347.541
• Mol file: 897920-56-8.mol

Synonyms:(+)-(1'S,2'S,2S,3S)-3-tert-butyl-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-2,N-dimethylheptanamide

Chemical Property of (+)-(1'S,2'S,2S,3S)-3-tert-butyl-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-2,N-dimethylheptanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+)-(1'S,2'S,2S,3S)-3-tert-butyl-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-2,N-dimethylheptanamide

There total 1 articles about (+)-(1'S,2'S,2S,3S)-3-tert-butyl-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-2,N-dimethylheptanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

n-butyllithium (109-72-8,29786-93-4) + methyl iodide (74-88-4) + E-(+)-(1'S,2'S)-N-methyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)-4,4-dimethylpent-2-enamide (678991-35-0) → (1'S,2'S)-3-tert-butyl-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-2,N-dimethylheptanamide + (+)-(1'S,2'S,2S,3S)-3-tert-butyl-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-2,N-dimethylheptanamide (897920-56-8)

Guidance literature:

n-butyllithium; E-(+)-(1'S,2'S)-N-methyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)-4,4-dimethylpent-2-enamide; With lithium chloride; In tetrahydrofuran; hexane; at -105 ℃;

methyl iodide; In tetrahydrofuran; hexane; at 0 ℃; for 5h;

DOI:10.1021/ol060720w

Reference yield:

(+)-(1'S,2'S,2S,3S)-3-tert-butyl-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-2,N-dimethylheptanamide (897920-56-8) + acetic acid (64-19-7,77671-22-8) → (2S,3S)-3-tert-Butyl-2-methyl-heptanoic acid (1S,2S)-2-methylamino-1-phenyl-propyl ester; compound with acetic acid

Guidance literature:

In 1,4-dioxane; for 12h; Heating;

DOI:10.1021/jo061205e

Reference yield:

(+)-(1'S,2'S,2S,3S)-3-tert-butyl-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-2,N-dimethylheptanamide (897920-56-8) + acetic acid (64-19-7,77671-22-8) → (2S,3S)-3-tert-Butyl-2-methyl-heptanoic acid (1R,2S)-2-methylamino-1-phenyl-propyl ester; compound with acetic acid

Guidance literature:

for 12h; Heating;

DOI:10.1021/ol060720w

upstream raw materials:

n-butyllithium

methyl iodide

E-(+)-(1'S,2'S)-N-methyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)-4,4-dimethylpent-2-enamide