benzhydryl 6α-<3'-<(tert-butyldimethylsilyl)oxy>propynyl>-6β-hydroxypenicillinate

Base Information

Chemical Name:benzhydryl 6α-<3'-<(tert-butyldimethylsilyl)oxy>propynyl>-6β-hydroxypenicillinate
CAS No.:147486-92-8
Molecular Formula:C₃₀H₃₇NO₅SSi
Molecular Weight:551.779
Hs Code.:

Synonyms:benzhydryl 6α-<3'-<(tert-butyldimethylsilyl)oxy>propynyl>-6β-hydroxypenicillinate

Suppliers and Price of benzhydryl 6α-<3'-<(tert-butyldimethylsilyl)oxy>propynyl>-6β-hydroxypenicillinate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of benzhydryl 6α-<3'-<(tert-butyldimethylsilyl)oxy>propynyl>-6β-hydroxypenicillinate

Chemical Property:

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Technology Process of benzhydryl 6α-<3'-<(tert-butyldimethylsilyl)oxy>propynyl>-6β-hydroxypenicillinate

There total 4 articles about benzhydryl 6α-<3'-<(tert-butyldimethylsilyl)oxy>propynyl>-6β-hydroxypenicillinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 551-16-6
6-Aminopenicillanic Acid

: 147486-92-8
benzhydryl 6α-<3'-<(tert-butyldimethylsilyl)oxy>propynyl>-6β-hydroxypenicillinate

Guidance literature:: Multi-step reaction with 4 steps

1: 32 percent / 70percent HClO₄, NaNO₂ / H₂O / 0.33 h / -5 - 0 °C

2: 42 percent / ethyl acetate; diethyl ether / 5 h / Ambient temperature

3: 97 percent / trifluoroacetic anhydride, dimethyl sulfoxide / CH₂Cl₂ / 1 h / -78 °C

With perchloric acid; dimethyl sulfoxide; trifluoroacetic anhydride; sodium nitrite; In diethyl ether; dichloromethane; water; ethyl acetate;
DOI:10.1021/jo00058a008

Reference yield:

: 15058-64-7
6-α-hydroxypenicillanic acid

: 147486-92-8
benzhydryl 6α-<3'-<(tert-butyldimethylsilyl)oxy>propynyl>-6β-hydroxypenicillinate

Guidance literature:: Multi-step reaction with 3 steps

1: 42 percent / ethyl acetate; diethyl ether / 5 h / Ambient temperature

2: 97 percent / trifluoroacetic anhydride, dimethyl sulfoxide / CH₂Cl₂ / 1 h / -78 °C

With dimethyl sulfoxide; trifluoroacetic anhydride; In diethyl ether; dichloromethane; ethyl acetate;
DOI:10.1021/jo00058a008

Reference yield:

: 51056-28-1
benzhydryl 6α-hydroxypenicillinate

: 147486-92-8
benzhydryl 6α-<3'-<(tert-butyldimethylsilyl)oxy>propynyl>-6β-hydroxypenicillinate

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / trifluoroacetic anhydride, dimethyl sulfoxide / CH₂Cl₂ / 1 h / -78 °C

With dimethyl sulfoxide; trifluoroacetic anhydride; In dichloromethane;
DOI:10.1021/jo00058a008