2-[2-(5-methyl-3-phenyl-isoxazol-4-yl)-ethyl]-thiazole-5-carboxylic acid isopropyl amide

Base Information

• Chemical Name: 2-[2-(5-methyl-3-phenyl-isoxazol-4-yl)-ethyl]-thiazole-5-carboxylic acid isopropyl amide
• CAS No.: 1254968-50-7
• Molecular Formula: C₁₉H₂₁N₃O₂S
• Molecular Weight: 355.461
• Mol file: 1254968-50-7.mol

Synonyms:2-[2-(5-methyl-3-phenyl-isoxazol-4-yl)-ethyl]-thiazole-5-carboxylic acid isopropyl amide

Chemical Property of 2-[2-(5-methyl-3-phenyl-isoxazol-4-yl)-ethyl]-thiazole-5-carboxylic acid isopropyl amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[2-(5-methyl-3-phenyl-isoxazol-4-yl)-ethyl]-thiazole-5-carboxylic acid isopropyl amide

There total 3 articles about 2-[2-(5-methyl-3-phenyl-isoxazol-4-yl)-ethyl]-thiazole-5-carboxylic acid isopropyl amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

2-[2-(5-methyl-3-phenyl-isoxazol-4-yl)-ethyl]-thiazole-5-carboxylic acid (1254969-89-5) + isopropylamine (75-31-0) → 2-[2-(5-methyl-3-phenyl-isoxazol-4-yl)-ethyl]-thiazole-5-carboxylic acid isopropyl amide (1254968-50-7)

Guidance literature:

isopropylamine; With trimethylaluminum; In 1,4-dioxane; toluene; at 20 ℃; for 1h; Inert atmosphere;

2-[2-(5-methyl-3-phenyl-isoxazol-4-yl)-ethyl]-thiazole-5-carboxylic acid; In 1,4-dioxane; toluene; at 90 ℃; for 3h;

Reference yield:

2-methyl-1,3-thiazole-5-carboxylic acid (40004-69-1) → 2-[2-(5-methyl-3-phenyl-isoxazol-4-yl)-ethyl]-thiazole-5-carboxylic acid isopropyl amide (1254968-50-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / -72 °C / Inert atmosphere

1.2: 1 h

2.1: trimethylaluminum / 1,4-dioxane; toluene / 1 h / 20 °C / Inert atmosphere

2.2: 3 h / 90 °C

With trimethylaluminum; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; toluene;

Reference yield:

ethyl 2-methylthiazole-5-carboxylate (79836-78-5) → 2-[2-(5-methyl-3-phenyl-isoxazol-4-yl)-ethyl]-thiazole-5-carboxylic acid isopropyl amide (1254968-50-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: water; sodium hydroxide / 1,4-dioxane / 1 h / 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / -72 °C / Inert atmosphere

2.2: 1 h

3.1: trimethylaluminum / 1,4-dioxane; toluene / 1 h / 20 °C / Inert atmosphere

3.2: 3 h / 90 °C

With water; trimethylaluminum; sodium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; toluene;

upstream raw materials:

2-[2-(5-methyl-3-phenyl-isoxazol-4-yl)-ethyl]-thiazole-5-carboxylic acid

isopropylamine

2-methyl-1,3-thiazole-5-carboxylic acid

ethyl 2-methylthiazole-5-carboxylate

Refernces