2-[2-(5-methyl-3-phenyl-isoxazol-4-yl)-ethyl]-thiazole-5-carboxylic acid isopropyl amide

Base Information

Chemical Name:2-[2-(5-methyl-3-phenyl-isoxazol-4-yl)-ethyl]-thiazole-5-carboxylic acid isopropyl amide
CAS No.:1254968-50-7
Molecular Formula:C₁₉H₂₁N₃O₂S
Molecular Weight:355.461
Hs Code.:

Synonyms:2-[2-(5-methyl-3-phenyl-isoxazol-4-yl)-ethyl]-thiazole-5-carboxylic acid isopropyl amide

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Chemical Property of 2-[2-(5-methyl-3-phenyl-isoxazol-4-yl)-ethyl]-thiazole-5-carboxylic acid isopropyl amide

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Technology Process of 2-[2-(5-methyl-3-phenyl-isoxazol-4-yl)-ethyl]-thiazole-5-carboxylic acid isopropyl amide

There total 3 articles about 2-[2-(5-methyl-3-phenyl-isoxazol-4-yl)-ethyl]-thiazole-5-carboxylic acid isopropyl amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1254969-89-5
2-[2-(5-methyl-3-phenyl-isoxazol-4-yl)-ethyl]-thiazole-5-carboxylic acid

: 75-31-0
isopropylamine

: 1254968-50-7
2-[2-(5-methyl-3-phenyl-isoxazol-4-yl)-ethyl]-thiazole-5-carboxylic acid isopropyl amide

Guidance literature:: isopropylamine; With trimethylaluminum; In 1,4-dioxane; toluene; at 20 ℃; for 1h; Inert atmosphere;

2-[2-(5-methyl-3-phenyl-isoxazol-4-yl)-ethyl]-thiazole-5-carboxylic acid; In 1,4-dioxane; toluene; at 90 ℃; for 3h;

Reference yield:

: 40004-69-1
2-methyl-1,3-thiazole-5-carboxylic acid

: 1254968-50-7
2-[2-(5-methyl-3-phenyl-isoxazol-4-yl)-ethyl]-thiazole-5-carboxylic acid isopropyl amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / -72 °C / Inert atmosphere

1.2: 1 h

2.1: trimethylaluminum / 1,4-dioxane; toluene / 1 h / 20 °C / Inert atmosphere

2.2: 3 h / 90 °C

With trimethylaluminum; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; toluene;

Reference yield:

: 79836-78-5
ethyl 2-methylthiazole-5-carboxylate

: 1254968-50-7
2-[2-(5-methyl-3-phenyl-isoxazol-4-yl)-ethyl]-thiazole-5-carboxylic acid isopropyl amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: water; sodium hydroxide / 1,4-dioxane / 1 h / 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / -72 °C / Inert atmosphere

2.2: 1 h

3.1: trimethylaluminum / 1,4-dioxane; toluene / 1 h / 20 °C / Inert atmosphere

3.2: 3 h / 90 °C

With water; trimethylaluminum; sodium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; toluene;