2-(2-(2-(2-((4-(1-(tert-butoxycarbonyl)piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)-4-methylphenyl)acetic acid

Base Information

Chemical Name:2-(2-(2-(2-((4-(1-(tert-butoxycarbonyl)piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)-4-methylphenyl)acetic acid
CAS No.:1566585-00-9
Molecular Formula:C₃₂H₃₇F₃N₄O₄
Molecular Weight:598.665
Hs Code.:

Synonyms:2-(2-(2-(2-((4-(1-(tert-butoxycarbonyl)piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)-4-methylphenyl)acetic acid

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Chemical Property of 2-(2-(2-(2-((4-(1-(tert-butoxycarbonyl)piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)-4-methylphenyl)acetic acid

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Technology Process of 2-(2-(2-(2-((4-(1-(tert-butoxycarbonyl)piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)-4-methylphenyl)acetic acid

There total 10 articles about 2-(2-(2-(2-((4-(1-(tert-butoxycarbonyl)piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)-4-methylphenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1566584-98-2
tert-butyl 4-(4-((4-(2-(2-methoxy-2-oxoethyl)-5-methylphenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate

: 1566585-00-9
2-(2-(2-(2-((4-(1-(tert-butoxycarbonyl)piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)-4-methylphenyl)acetic acid

Guidance literature:: With lithium hydroxide monohydrate; water; In tetrahydrofuran; methanol; at 20 ℃; for 27h;

Reference yield:

: 7697-27-0
2-bromo-4-methylbenzoic acid

: 1566585-00-9
2-(2-(2-(2-((4-(1-(tert-butoxycarbonyl)piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)-4-methylphenyl)acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: oxalyl dichloride / tetrahydrofuran; N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

1.2: 1 h / 0 - 20 °C / Inert atmosphere

2.1: triethylamine; silver benzoate / tetrahydrofuran / 2 h / 20 °C

3.1: copper(l) iodide; tri tert-butylphosphoniumtetrafluoroborate; triethylamine; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 17 h / 70 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran; dichloromethane / 0.08 h / 0 - 20 °C

5.1: copper(l) iodide; triethylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 0.25 h / 120 °C / Microwave irradiation

6.1: triethylamine; palladium 10% on activated carbon; hydrogen / water; N,N-dimethyl-formamide / 16 h / 20 °C

7.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 27 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; oxalyl dichloride; lithium hydroxide monohydrate; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; water; hydrogen; silver benzoate; triethylamine; triphenylphosphine; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1566584-96-0
tert-butyl 4-(4-((4-((2-(2-methoxy-2-oxoethyl)-5-methylphenyl)ethynyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate

: 1566585-00-9
2-(2-(2-(2-((4-(1-(tert-butoxycarbonyl)piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)-4-methylphenyl)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; palladium 10% on activated carbon; hydrogen / water; N,N-dimethyl-formamide / 16 h / 20 °C

2: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 27 h / 20 °C

With lithium hydroxide monohydrate; palladium 10% on activated carbon; water; hydrogen; triethylamine; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;