tert-butyl 4-(4-((4-(2-(2-amino-2-oxoethyl)-5-methylphenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(4-((4-(2-(2-amino-2-oxoethyl)-5-methylphenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate
CAS No.:1566585-02-1
Molecular Formula:C₃₂H₃₈F₃N₅O₃
Molecular Weight:597.681
Hs Code.:

Synonyms:tert-butyl 4-(4-((4-(2-(2-amino-2-oxoethyl)-5-methylphenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate

Suppliers and Price of tert-butyl 4-(4-((4-(2-(2-amino-2-oxoethyl)-5-methylphenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl 4-(4-((4-(2-(2-amino-2-oxoethyl)-5-methylphenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl 4-(4-((4-(2-(2-amino-2-oxoethyl)-5-methylphenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate

There total 11 articles about tert-butyl 4-(4-((4-(2-(2-amino-2-oxoethyl)-5-methylphenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1566585-00-9
2-(2-(2-(2-((4-(1-(tert-butoxycarbonyl)piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)-4-methylphenyl)acetic acid

: 1566585-02-1
tert-butyl 4-(4-((4-(2-(2-amino-2-oxoethyl)-5-methylphenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate

Guidance literature:: With ammonium carbonate; N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 - 25 ℃; for 42.3333h; Inert atmosphere;

Reference yield:

: 1069114-83-5
methyl 2-(2-bromo-4-methylphenyl)acetate

: 1566585-02-1
tert-butyl 4-(4-((4-(2-(2-amino-2-oxoethyl)-5-methylphenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: copper(l) iodide; tri tert-butylphosphoniumtetrafluoroborate; triethylamine; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 17 h / 70 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran; dichloromethane / 0.08 h / 0 - 20 °C

3: copper(l) iodide; triethylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 0.25 h / 120 °C / Microwave irradiation

4: triethylamine; palladium 10% on activated carbon; hydrogen / water; N,N-dimethyl-formamide / 16 h / 20 °C

5: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 27 h / 20 °C

6: N-ethyl-N,N-diisopropylamine; ammonium carbonate; benzotriazol-1-ol; N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride / tetrahydrofuran; N,N-dimethyl-formamide / 42.33 h / 20 - 25 °C / Inert atmosphere

With ammonium carbonate; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; lithium hydroxide monohydrate; N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; water; hydrogen; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 7697-27-0
2-bromo-4-methylbenzoic acid

: 1566585-02-1
tert-butyl 4-(4-((4-(2-(2-amino-2-oxoethyl)-5-methylphenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: oxalyl dichloride / tetrahydrofuran; N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

1.2: 1 h / 0 - 20 °C / Inert atmosphere

2.1: triethylamine; silver benzoate / tetrahydrofuran / 2 h / 20 °C

3.1: copper(l) iodide; tri tert-butylphosphoniumtetrafluoroborate; triethylamine; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 17 h / 70 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran; dichloromethane / 0.08 h / 0 - 20 °C

5.1: copper(l) iodide; triethylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 0.25 h / 120 °C / Microwave irradiation

6.1: triethylamine; palladium 10% on activated carbon; hydrogen / water; N,N-dimethyl-formamide / 16 h / 20 °C

7.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 27 h / 20 °C

8.1: N-ethyl-N,N-diisopropylamine; ammonium carbonate; benzotriazol-1-ol; N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride / tetrahydrofuran; N,N-dimethyl-formamide / 42.33 h / 20 - 25 °C / Inert atmosphere

With ammonium carbonate; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; oxalyl dichloride; lithium hydroxide monohydrate; N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; water; hydrogen; silver benzoate; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;