(1R,3S,4R,7S)-7-(tert-butyldimethylsilyl)oxy-1-(4,4'-dimethoxytrityl)oxymethyl-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane

Base Information

Chemical Name:(1R,3S,4R,7S)-7-(tert-butyldimethylsilyl)oxy-1-(4,4'-dimethoxytrityl)oxymethyl-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane
CAS No.:427889-64-3
Molecular Formula:C₃₈H₄₆N₂O₈Si
Molecular Weight:686.877
Hs Code.:

Synonyms:(1R,3S,4R,7S)-7-(tert-butyldimethylsilyl)oxy-1-(4,4'-dimethoxytrityl)oxymethyl-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane

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Chemical Property of (1R,3S,4R,7S)-7-(tert-butyldimethylsilyl)oxy-1-(4,4'-dimethoxytrityl)oxymethyl-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane

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Technology Process of (1R,3S,4R,7S)-7-(tert-butyldimethylsilyl)oxy-1-(4,4'-dimethoxytrityl)oxymethyl-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane

There total 9 articles about (1R,3S,4R,7S)-7-(tert-butyldimethylsilyl)oxy-1-(4,4'-dimethoxytrityl)oxymethyl-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: (1R,3S,4R,7S)-1-(4,4'-dimethoxytrityl)oxymethyl-7-hydroxy-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane

: 427889-64-3
(1R,3S,4R,7S)-7-(tert-butyldimethylsilyl)oxy-1-(4,4'-dimethoxytrityl)oxymethyl-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane

Guidance literature:: With pyridine; 1H-imidazole; at 20 ℃; for 142h;
DOI:10.1002/1521-3765(20020201)8:3<712::AID-CHEM712>3.0.CO;2-0

Reference yield:

: 65-71-4,28806-14-6,691841-57-3
thymin

: 427889-64-3
(1R,3S,4R,7S)-7-(tert-butyldimethylsilyl)oxy-1-(4,4'-dimethoxytrityl)oxymethyl-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane

Guidance literature:: Multi-step reaction with 4 steps

1: 51 percent / H₂ / 20percent Pd(OH)2/C / ethanol / 120 h / 20 °C

2: 71 percent / pyridine; AgNO₃ / dimethylformamide; tetrahydrofuran / 22 h / 20 °C

3: 79 percent / imidazole; pyridine / 142 h / 20 °C

With pyridine; 1H-imidazole; hydrogen; silver nitrate; 20percent Pd(OH)2/C; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1002/1521-3765(20020201)8:3<712::AID-CHEM712>3.0.CO;2-0

Reference yield:

: 219854-35-0
methyl 3,5-di-O-benzyl-4-C-methylsulfonyloxymethyl-α,β-D-ribofuranoside

: 427889-64-3
(1R,3S,4R,7S)-7-(tert-butyldimethylsilyl)oxy-1-(4,4'-dimethoxytrityl)oxymethyl-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane

Guidance literature:: Multi-step reaction with 4 steps

1: 51 percent / H₂ / 20percent Pd(OH)2/C / ethanol / 120 h / 20 °C

2: 71 percent / pyridine; AgNO₃ / dimethylformamide; tetrahydrofuran / 22 h / 20 °C

3: 79 percent / imidazole; pyridine / 142 h / 20 °C

With pyridine; 1H-imidazole; hydrogen; silver nitrate; 20percent Pd(OH)2/C; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1002/1521-3765(20020201)8:3<712::AID-CHEM712>3.0.CO;2-0