tert-butyl 2-chloro-4-(1-oxo-1-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methylamino)propan-2-yl)benzylcarbamate

Base Information

Chemical Name:tert-butyl 2-chloro-4-(1-oxo-1-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methylamino)propan-2-yl)benzylcarbamate
CAS No.:1428765-34-7
Molecular Formula:C₂₉H₃₁ClF₃N₃O₃
Molecular Weight:562.032
Hs Code.:

Synonyms:tert-butyl 2-chloro-4-(1-oxo-1-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methylamino)propan-2-yl)benzylcarbamate

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Chemical Property of tert-butyl 2-chloro-4-(1-oxo-1-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methylamino)propan-2-yl)benzylcarbamate

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Technology Process of tert-butyl 2-chloro-4-(1-oxo-1-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methylamino)propan-2-yl)benzylcarbamate

There total 11 articles about tert-butyl 2-chloro-4-(1-oxo-1-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methylamino)propan-2-yl)benzylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1428765-33-6
2-(3-chloro-4-cyanophenyl)-N-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

: 1428765-34-7
tert-butyl 2-chloro-4-(1-oxo-1-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methylamino)propan-2-yl)benzylcarbamate

Guidance literature:: di-tert-butyl dicarbonate; 2-(3-chloro-4-cyanophenyl)-N-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide; With sodium tetrahydroborate; nickel (II) chloride hexahydrate; In methanol; at 0 - 20 ℃; for 1h;

With 3-azapentane-1,5-diamine; In methanol; at 20 ℃; for 1h;

Reference yield:

: 1428765-32-5
(2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methanamine

: 1428765-34-7
tert-butyl 2-chloro-4-(1-oxo-1-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methylamino)propan-2-yl)benzylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / acetonitrile / 15 h / 20 °C

2.1: nickel(II) chloride hexahydrate; sodium tetrahydroborate; methanol / 1 h / 0 - 20 °C

2.2: 1 h

With methanol; sodium tetrahydroborate; nickel(II) chloride hexahydrate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In acetonitrile;

Reference yield:

: 33697-81-3
(3-chloro-4-hydroxy-phenyl)-acetic acid

: 1428765-34-7
tert-butyl 2-chloro-4-(1-oxo-1-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methylamino)propan-2-yl)benzylcarbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sulfuric acid / 15 h / Reflux

2.1: triethylamine / dichloromethane / 2 h / 0 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 34 h / 80 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C

5.1: sodium hydroxide; water / tetrahydrofuran / 15 h / 20 °C

5.2: pH 3 - 4

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / acetonitrile / 15 h / 20 °C

7.1: nickel(II) chloride hexahydrate; sodium tetrahydroborate; methanol / 1 h / 0 - 20 °C

7.2: 1 h

With methanol; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; nickel(II) chloride hexahydrate; sulfuric acid; water; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile; mineral oil;