2-(3-methoxy-4-(methylsulfonamidomethyl)phenyl)-N-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

Base Information

Chemical Name:2-(3-methoxy-4-(methylsulfonamidomethyl)phenyl)-N-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide
CAS No.:1428764-93-5
Molecular Formula:C₂₆H₂₈F₃N₃O₄S
Molecular Weight:535.587
Hs Code.:

Synonyms:2-(3-methoxy-4-(methylsulfonamidomethyl)phenyl)-N-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

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Chemical Property of 2-(3-methoxy-4-(methylsulfonamidomethyl)phenyl)-N-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

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Technology Process of 2-(3-methoxy-4-(methylsulfonamidomethyl)phenyl)-N-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

There total 22 articles about 2-(3-methoxy-4-(methylsulfonamidomethyl)phenyl)-N-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 1428765-39-2
2-(4-(aminomethyl)-3-methoxyphenyl)-N-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

: 124-63-0
methanesulfonyl chloride

: 1428764-93-5
2-(3-methoxy-4-(methylsulfonamidomethyl)phenyl)-N-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

Guidance literature:: With pyridine; at 0 - 20 ℃; for 15h;

Reference yield: 22.0%

: 1428765-36-9
2-(4-(aminomethyl)-3-chlorophenyl)-N-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

: 124-63-0
methanesulfonyl chloride

: 1428764-93-5
2-(3-methoxy-4-(methylsulfonamidomethyl)phenyl)-N-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

Guidance literature:: With pyridine; at 0 - 20 ℃; for 15h;

Reference yield:

: 1428765-32-5
(2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methanamine

: 1428764-93-5
2-(3-methoxy-4-(methylsulfonamidomethyl)phenyl)-N-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / acetonitrile / 15 h / 20 °C

2.1: nickel(II) chloride hexahydrate; sodium tetrahydroborate; methanol / 1 h / 0 - 20 °C

2.2: 1 h

3.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

3.2: pH 8 - 9

4.1: pyridine / 15 h / 0 - 20 °C

With pyridine; methanol; sodium tetrahydroborate; nickel(II) chloride hexahydrate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In dichloromethane; acetonitrile;