((1S,2S,10bS)-2-(2-hydroxyethyl)-1-phenyl-1,2,5,6-tetrahydropyrazolo[5,1-a]isoquinolin-3(10bH)-yl)(phenyl)methanone

Base Information

Chemical Name:((1S,2S,10bS)-2-(2-hydroxyethyl)-1-phenyl-1,2,5,6-tetrahydropyrazolo[5,1-a]isoquinolin-3(10bH)-yl)(phenyl)methanone
CAS No.:1621598-63-7
Molecular Formula:C₂₆H₂₆N₂O₂
Molecular Weight:398.505
Hs Code.:

Synonyms:((1S,2S,10bS)-2-(2-hydroxyethyl)-1-phenyl-1,2,5,6-tetrahydropyrazolo[5,1-a]isoquinolin-3(10bH)-yl)(phenyl)methanone

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Chemical Property of ((1S,2S,10bS)-2-(2-hydroxyethyl)-1-phenyl-1,2,5,6-tetrahydropyrazolo[5,1-a]isoquinolin-3(10bH)-yl)(phenyl)methanone

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Technology Process of ((1S,2S,10bS)-2-(2-hydroxyethyl)-1-phenyl-1,2,5,6-tetrahydropyrazolo[5,1-a]isoquinolin-3(10bH)-yl)(phenyl)methanone

There total 4 articles about ((1S,2S,10bS)-2-(2-hydroxyethyl)-1-phenyl-1,2,5,6-tetrahydropyrazolo[5,1-a]isoquinolin-3(10bH)-yl)(phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 55177-35-0,13910-23-1
4-phenylbut-2-enal

: C₁₆H₁₆N₂O₂

: 1621598-63-7
((1S,2S,10bS)-2-(2-hydroxyethyl)-1-phenyl-1,2,5,6-tetrahydropyrazolo[5,1-a]isoquinolin-3(10bH)-yl)(phenyl)methanone

Guidance literature:: 4-phenylbut-2-enal; C₁₆H₁₆N₂O₂; With (2S)-2-{diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine; In dichloromethane; at 0 ℃; for 24h;

With sodium tetrahydroborate; In ethanol; dichloromethane; at 0 ℃; enantioselective reaction;
DOI:10.1021/jo5018519

Reference yield:

: 1632445-80-7
C₂₆H₂₄N₂O₂

: 1621598-63-7
((1S,2S,10bS)-2-(2-hydroxyethyl)-1-phenyl-1,2,5,6-tetrahydropyrazolo[5,1-a]isoquinolin-3(10bH)-yl)(phenyl)methanone

Guidance literature:: With sodium tetrahydroborate; In methanol; at 20 ℃; for 2h; Reagent/catalyst; enantioselective reaction;
DOI:10.1002/chem.201402089

Reference yield:

: 42046-26-4
benzoyl(3,4-dihydroisoquinolinium-2-yl)azanide

: 1621598-63-7
((1S,2S,10bS)-2-(2-hydroxyethyl)-1-phenyl-1,2,5,6-tetrahydropyrazolo[5,1-a]isoquinolin-3(10bH)-yl)(phenyl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: 2,4-dinitrobenzoic acid; (S)-2-{bis[3,5-bis(trifluoromethyl)phenyl][(trimethylsilanyl)oxy]methyl}pyrrolidine / dichloromethane / 12 h / -20 °C

2: sodium tetrahydroborate / methanol / 2 h / 20 °C

With (S)-2-{bis[3,5-bis(trifluoromethyl)phenyl][(trimethylsilanyl)oxy]methyl}pyrrolidine; sodium tetrahydroborate; 2,4-dinitrobenzoic acid; In methanol; dichloromethane;
DOI:10.1002/chem.201402089