Technology Process of 4-(pentafluoroethyl)-2-nitrophenol
There total 4 articles about 4-(pentafluoroethyl)-2-nitrophenol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sulfuric acid; nitric acid; acetic acid;
In
water;
at 20 ℃;
for 3h;
Cooling with ice;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: copper(l) iodide / N,N-dimethyl-formamide; toluene / 6 h / 140 - 170 °C
2: hydrogenchloride; water / acetone / 2.5 h / 50 °C
3: nitric acid; sulfuric acid; acetic acid / 3 h / 20 °C / Cooling with ice
With
hydrogenchloride; copper(l) iodide; sulfuric acid; water; nitric acid; acetic acid;
In
N,N-dimethyl-formamide; acetone; toluene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / Cooling with ice
1.2: 1 h / 20 °C
2.1: copper(l) iodide / N,N-dimethyl-formamide; toluene / 6 h / 140 - 170 °C
3.1: hydrogenchloride; water / acetone / 2.5 h / 50 °C
4.1: nitric acid; sulfuric acid; acetic acid / 3 h / 20 °C / Cooling with ice
With
hydrogenchloride; copper(l) iodide; sulfuric acid; water; nitric acid; sodium hydride; acetic acid;
In
N,N-dimethyl-formamide; acetone; toluene; mineral oil;
