(R)-2-chloro-5-(4-(methylsulfonyl)benzyl)-5,6,6a,7,9,10-hexahydro-[1,4]oxazino[3,4-h]pteridine

Base Information

Chemical Name:(R)-2-chloro-5-(4-(methylsulfonyl)benzyl)-5,6,6a,7,9,10-hexahydro-[1,4]oxazino[3,4-h]pteridine
CAS No.:1394070-56-4
Molecular Formula:C₁₇H₁₉ClN₄O₃S
Molecular Weight:394.882
Hs Code.:

Synonyms:(R)-2-chloro-5-(4-(methylsulfonyl)benzyl)-5,6,6a,7,9,10-hexahydro-[1,4]oxazino[3,4-h]pteridine

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Chemical Property of (R)-2-chloro-5-(4-(methylsulfonyl)benzyl)-5,6,6a,7,9,10-hexahydro-[1,4]oxazino[3,4-h]pteridine

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Technology Process of (R)-2-chloro-5-(4-(methylsulfonyl)benzyl)-5,6,6a,7,9,10-hexahydro-[1,4]oxazino[3,4-h]pteridine

There total 3 articles about (R)-2-chloro-5-(4-(methylsulfonyl)benzyl)-5,6,6a,7,9,10-hexahydro-[1,4]oxazino[3,4-h]pteridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 1394070-49-5
(R)-2-chloro-5,6,6a,7,9,10-hexahydro-[1,4]oxazino[3,4-h]pteridine

: 53606-06-7
4-(methylsulfonyl)benzyl bromide

: 1394070-56-4
(R)-2-chloro-5-(4-(methylsulfonyl)benzyl)-5,6,6a,7,9,10-hexahydro-[1,4]oxazino[3,4-h]pteridine

Guidance literature:: With potassium tert-butylate; In dimethyl sulfoxide; at 20 ℃;

Reference yield:

: 1394070-48-4
2-chloro-5,6,6a,7,9,10-hexahydro-[1,4]oxazino[3,4-h]pteridine

: 1394070-56-4
(R)-2-chloro-5-(4-(methylsulfonyl)benzyl)-5,6,6a,7,9,10-hexahydro-[1,4]oxazino[3,4-h]pteridine

Guidance literature:: Multi-step reaction with 2 steps

1: Chiralcel_.(R). AS-H / carbon dioxide; methanol / Resolution of racemate

2: potassium tert-butylate / dimethyl sulfoxide / 20 °C

With potassium tert-butylate; In methanol; carbon dioxide; dimethyl sulfoxide;

Reference yield:

: 1268474-50-5
2-chloro-6a,7,9,10-tetrahydro[1,4]oxazino[3,4-h]pteridin -6(5H)-one

: 1394070-56-4
(R)-2-chloro-5-(4-(methylsulfonyl)benzyl)-5,6,6a,7,9,10-hexahydro-[1,4]oxazino[3,4-h]pteridine

Guidance literature:: Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

2: Chiralcel_.(R). AS-H / carbon dioxide; methanol / Resolution of racemate

3: potassium tert-butylate / dimethyl sulfoxide / 20 °C

With lithium aluminium tetrahydride; potassium tert-butylate; In tetrahydrofuran; methanol; carbon dioxide; dimethyl sulfoxide;