53606-06-7

Usage

Chemical Properties

white to beige crystalline powder

InChI:InChI=1/C8H9BrO2S/c1-12(10,11)8-4-2-7(6-9)3-5-8/h2-5H,6H2,1H3

Upstream product

• 22821-77-8 p-methylsulfonylbenzyl alcohol 
• 3446-90-0 4-(methylthio)benzyl alcohol 
• 4052-30-6 4-methylsulfonylbenzoic acid 
• 6274-54-0 methylsulfonyl-4 benzoate d'ethyle 
• 40913-92-6 4-methylsulfonylbenzoyl chloride 
• 5398-77-6 para-methanesulfonylbenzaldehyde 

Downstream Products

• 100960-84-7 (4-iodomethyl-phenyl)-methyl sulfone 
• 91645-32-8 4-(4-methanesulfonyl-benzyl)-morpholine 
• 92222-28-1 (4-Methylsulfonyl-benzyl)-isothiuronium 
• 3614-04-8 α,α-Dichlor-N-methyl-p-(4-methylsulfonyl-benzyloxy)-acetanilid 
• 101090-96-4 4-Methylsulfonyl-α-(4-nitro-2-methoxy-phenoxy)-toluol 
• 5398-77-6 para-methanesulfonylbenzaldehyde 
• 22821-77-8 p-methylsulfonylbenzyl alcohol 
• 160032-29-1 3-thienyl 4-methylsulfonylbenzyl sulfide 
• 849035-67-2 2-nitro-4-(methylsulphonyl)benzyl bromide 
• 93629-02-8 p-methylsulfonylbenzyl mercaptan 

Relevant academic research and scientific papers

SPIRO COMPOUNDS AS GLYCOSIDASE INHIBITORS

Compounds of formula (I) wherein A, R, L, Z, Q1, Q2 and n have the meaning according to the claims can be employed, inter alia, for the treatment of tauopathies and Alzheimer's disease.

INDOLE AND AZAINDOLE HALOALLYLAMINE DERIVATIVE INHIBITORS OF LYSYL OXIDASES AND USES THEREOF

The present invention relates to novel compounds which are capable of inhibiting certain amine oxidase enzymes. These compounds are useful for treatment of a variety of indications, e.g., fibrosis, cancer and/or angiogenesis in human subjects as well as i

Synthesis of unsymmetrical 3,4-diaryl-3-pyrrolin-2-ones utilizing pyrrole weinreb amides

A regiocontrolled synthesis of unsymmetrical 3,4-diaryl-3-pyrrolin-2-ones has been achieved in three steps from 1,2-diaryl-1-nitroethenes with pyrrole-2-carboxamides (pyrrole Weinreb amides) serving as the key linchpin intermediates. Two different methods for the preparation of the requisite nitroalkenes were investigated: (1) modified Henry reaction between arylnitromethanes and arylimines; and (2) Suzuki-Miyaura cross-coupling reaction of 2-aryl-1-bromo-1-nitroethenes with arylboronic acids. Some difficulty was encountered in the preparation of arylnitromethanes, thus leading to the exploration of a cross-coupling strategy that proved more useful. A Barton-Zard pyrrole cyclocondensation reaction between 1,2-diaryl-1-nitroethenes and N-methoxy-N-methyl-2-isocyanoacetamide gave the corresponding pyrrole Weinreb amides, which were then converted into the desired 3-pyrrolin-2-ones in two steps. Overall, this method allowed for the construction of 3,4-diaryl-3- pyrrolin-2-ones with complete regiocontrol of the substituents with respect to the lactam carbonyl. The utility of this synthetic methodology was demonstrated by the preparation of eight unsymmetrical and symmetrical 3,4-diaryl-3-pyrrolin- 2-ones including the N-H lactam analogue of the selective COX-II inhibitor, rofecoxib.

Synthesis and antirhinovirus activity of 6-(dimethylamino)-2-(trifluoromethyl)-9-(substituted benzyl)-9H-purines

A series of 6-(dimethylamino)-2-(trifluoromethyl)-9-(substituted benzyl)purines was synthesized and tested for antirhinovirus activity. Most of the compounds were synthesized by alkylation of 6-chloro-2-(trifluoromethyl)-9H-purine with the appropriate benzyl halide followed by displacement of the chloro group with dimethylamine. Alternatively, 6-(dimethylamino)-2-(trifluoromethyl)purine was alkylated with the appropriate benzyl halide. Although several different aryl substituents provided compounds with IC50's = 0.03 μM against rhinovirus serotype 1B, no congener was significantly more active than the parent 2. Twenty-three compounds were tested against 18 other serotypes, but none exhibited a uniform profile of activity.

Substituent effects on benzyl radical hyperfine coupling constants. Part 2. The effect of sulphur substituents

Several 4-substituted benzyl radicals of the general form R(On)SC5H4CH2. (n=0, 1, 2; R=Me, Ph, Tol, COCH3, OCH3) have been investigated by electron spin resonance (esr) spectroscopy.In general, the ability to delocalize spin density onto the substituent decreases as n increases.The effect of R on the spin density depends on the oxidation state of the sulphur.These trends are explained by considering the sulphur to be eithr a spin donor or a spin acceptor, depending on the oxidation state.The ?.a valuesare determined.

Correlation pKa - activitee catalitique des thiols dans la reeaction d'hydrolyse de l'aceetate de p-nitropheenyle

The kinetic study of the hydrolysis of p-nitrophenylacetate in the presence of primary thiols indicates the thiolate anion as the sole catalytic species.Comparison of the true second order constants (kRS-) reveals that purely aliphatic primary thiols behave differently from aromatic α-substituted primary thiols.In the latter group a correlation can be established between the true second order rate constants and the pKSH values by means of the Broensted equation log kRS- = βpKSH + C, with β equal to 0.40 and C equal to -0.85.

7-(Substituted)-7H-pyrrolo[3,2-f]quinazoline-1,3-diamines

Pyrrolo[3,2-f]quinazoline-1,3-diamine and the 7-(substituted) and 7,8-disubstituted derivatives thereof, possess anti-bacterial activity in vitro. The invention also provides compounds having other biological effects, such as synergism in vivo with sulfa drugs against bacterial infections, activity in vivo against malarial infections, and anti-cancer activity in vivo. In addition, the compounds show anti-folic acid activity in in vitro tests.