N-[3-(dimethylamino)propyl]-1-methyl-4-[(1-[2-oxo-2-(p-tolylthio)ethyl]-4-{1-methyl-1H-imidazole-2-carboxamido}-1H-2-pyrrolyl)carboxamido]-1H-2-pyrrolecarboxamide

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Chemical Name:N-[3-(dimethylamino)propyl]-1-methyl-4-[(1-[2-oxo-2-(p-tolylthio)ethyl]-4-{1-methyl-1H-imidazole-2-carboxamido}-1H-2-pyrrolyl)carboxamido]-1H-2-pyrrolecarboxamide
CAS No.:1448855-91-1
Molecular Formula:C₃₀H₃₆N₈O₄S
Molecular Weight:604.733
Hs Code.:

N-[3-(dimethylamino)propyl]-1-methyl-4-[(1-[2-oxo-2-(p-tolylthio)ethyl]-4-{1-methyl-1H-imidazole-2-carboxamido}-1H-2-pyrrolyl)carboxamido]-1H-2-pyrrolecarboxamide

Synonyms:N-[3-(dimethylamino)propyl]-1-methyl-4-[(1-[2-oxo-2-(p-tolylthio)ethyl]-4-{1-methyl-1H-imidazole-2-carboxamido}-1H-2-pyrrolyl)carboxamido]-1H-2-pyrrolecarboxamide

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Chemical Property of N-[3-(dimethylamino)propyl]-1-methyl-4-[(1-[2-oxo-2-(p-tolylthio)ethyl]-4-{1-methyl-1H-imidazole-2-carboxamido}-1H-2-pyrrolyl)carboxamido]-1H-2-pyrrolecarboxamide

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Technology Process of N-[3-(dimethylamino)propyl]-1-methyl-4-[(1-[2-oxo-2-(p-tolylthio)ethyl]-4-{1-methyl-1H-imidazole-2-carboxamido}-1H-2-pyrrolyl)carboxamido]-1H-2-pyrrolecarboxamide

There total 7 articles about N-[3-(dimethylamino)propyl]-1-methyl-4-[(1-[2-oxo-2-(p-tolylthio)ethyl]-4-{1-methyl-1H-imidazole-2-carboxamido}-1H-2-pyrrolyl)carboxamido]-1H-2-pyrrolecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 115592-72-8
2-Bromthioessigsaeure-S-(p-tolyl)ester

: N-[3-(dimethylamino)propyl]-1-methyl-4-[(4-{1-methyl-1H-imidazole-2-carboxamido}-1H-2-pyrrolyl)carboxamido]-1H-2-pyrrolecarboxamide

: 1448855-91-1
N-[3-(dimethylamino)propyl]-1-methyl-4-[(1-[2-oxo-2-(p-tolylthio)ethyl]-4-{1-methyl-1H-imidazole-2-carboxamido}-1H-2-pyrrolyl)carboxamido]-1H-2-pyrrolecarboxamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; acetone; at 20 ℃; for 0.25h; Inert atmosphere;
DOI:10.1016/j.tet.2013.05.126

Reference yield:

: 913960-95-9
1-Methyl-4-[(4-nitro-1H-pyrrole-2-carbonyl)-amino]-1H-pyrrole-2-carboxylic acid (3-dimethylamino-propyl)-amide

: 1448855-91-1
N-[3-(dimethylamino)propyl]-1-methyl-4-[(1-[2-oxo-2-(p-tolylthio)ethyl]-4-{1-methyl-1H-imidazole-2-carboxamido}-1H-2-pyrrolyl)carboxamido]-1H-2-pyrrolecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen; palladium 10% on activated carbon / N,N-dimethyl-formamide; methanol / 1 h / 20 °C

2: dmap; diethyl cyanophosphonate; triethylamine / N,N-dimethyl-formamide; tetrahydrofuran / 15 h / -10 °C / Inert atmosphere

3: potassium carbonate / N,N-dimethyl-formamide; acetone / 0.25 h / 20 °C / Inert atmosphere

With dmap; diethyl cyanophosphonate; palladium 10% on activated carbon; hydrogen; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.tet.2013.05.126

Reference yield:

: 30148-21-1
ethyl 1-methyl-1H-imidazole-2-carboxylate

: 1448855-91-1
N-[3-(dimethylamino)propyl]-1-methyl-4-[(1-[2-oxo-2-(p-tolylthio)ethyl]-4-{1-methyl-1H-imidazole-2-carboxamido}-1H-2-pyrrolyl)carboxamido]-1H-2-pyrrolecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / water / 1 h / Reflux

1.2: pH 2

2.1: dmap; diethyl cyanophosphonate; triethylamine / N,N-dimethyl-formamide; tetrahydrofuran / 15 h / -10 °C / Inert atmosphere

3.1: potassium carbonate / N,N-dimethyl-formamide; acetone / 0.25 h / 20 °C / Inert atmosphere

With dmap; diethyl cyanophosphonate; potassium carbonate; triethylamine; sodium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.tet.2013.05.126