[3-({4'-[3-(dimethoxy-phosphorylmethyl)-phenylcarbamoyl]-[2,2']bipyridinyl-4-carbonyl}-amino)-benzyl]-phosphonic acid dimethyl ester

Base Information

Chemical Name:[3-({4'-[3-(dimethoxy-phosphorylmethyl)-phenylcarbamoyl]-[2,2']bipyridinyl-4-carbonyl}-amino)-benzyl]-phosphonic acid dimethyl ester
CAS No.:366490-48-4
Molecular Formula:C₃₀H₃₂N₄O₈P₂
Molecular Weight:638.554
Hs Code.:

Synonyms:[3-({4'-[3-(dimethoxy-phosphorylmethyl)-phenylcarbamoyl]-[2,2']bipyridinyl-4-carbonyl}-amino)-benzyl]-phosphonic acid dimethyl ester

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Chemical Property of [3-({4'-[3-(dimethoxy-phosphorylmethyl)-phenylcarbamoyl]-[2,2']bipyridinyl-4-carbonyl}-amino)-benzyl]-phosphonic acid dimethyl ester

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Technology Process of [3-({4'-[3-(dimethoxy-phosphorylmethyl)-phenylcarbamoyl]-[2,2']bipyridinyl-4-carbonyl}-amino)-benzyl]-phosphonic acid dimethyl ester

There total 3 articles about [3-({4'-[3-(dimethoxy-phosphorylmethyl)-phenylcarbamoyl]-[2,2']bipyridinyl-4-carbonyl}-amino)-benzyl]-phosphonic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 72460-28-7
2,2'-bipyridyl-4,4'-dicarboxylic acid chloride

: 152528-26-2
(3-amino-benzyl)-phosphonic acid dimethyl ester

: 366490-48-4
[3-({4'-[3-(dimethoxy-phosphorylmethyl)-phenylcarbamoyl]-[2,2']bipyridinyl-4-carbonyl}-amino)-benzyl]-phosphonic acid dimethyl ester

Guidance literature:: With triethylamine; In N,N-dimethyl acetamide; at 20 ℃; for 12h;
DOI:10.1021/ja010931q

Reference yield:

: 3958-57-4
1-bromomethyl-3-nitrobenzene

: 366490-48-4
[3-({4'-[3-(dimethoxy-phosphorylmethyl)-phenylcarbamoyl]-[2,2']bipyridinyl-4-carbonyl}-amino)-benzyl]-phosphonic acid dimethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 2 h / 100 °C

2: NaBH₄; NiCl₂

3: 65 percent / Et₃N / N,N-dimethyl-acetamide / 12 h / 20 °C

With sodium tetrahydroborate; triethylamine; nickel dichloride; In N,N-dimethyl acetamide;
DOI:10.1021/ja010931q

Reference yield:

: 152528-25-1
dimethyl (3-nitrophenyl)methyl phosphonate

: 366490-48-4
[3-({4'-[3-(dimethoxy-phosphorylmethyl)-phenylcarbamoyl]-[2,2']bipyridinyl-4-carbonyl}-amino)-benzyl]-phosphonic acid dimethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: NaBH₄; NiCl₂

2: 65 percent / Et₃N / N,N-dimethyl-acetamide / 12 h / 20 °C

With sodium tetrahydroborate; triethylamine; nickel dichloride; In N,N-dimethyl acetamide;
DOI:10.1021/ja010931q